(3a(2)S)-[1,3a(2)-Bipyrrolidin]-2-one | 550370-79-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (3a(2)S)-[1,3a(2)-Bipyrrolidin]-2-one
• 英文别名: 1-[(3S)-pyrrolidin-3-yl]pyrrolidin-2-one
• CAS: 550370-79-1
• 化学式: C₈H₁₄N₂O
• 分子量: 154.21
• InChiKey: KZPJDZAIPRJZBU-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20200172508A1

  公开（公告）日：2020-06-04

  The present invention encompasses compounds of the formula I which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.

  本发明涵盖了适用于治疗与Vanin相关疾病的化合物I的公式，以及制备这些化合物的方法、含有这些化合物的药物制剂，以及它们的使用方法。
• [EN] HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROAROMATIQUES UTILISÉS EN TANT QU'INHIBITEURS DE VANINE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2020114947A1

  公开（公告）日：2020-06-11

  The present invention encompasses compounds of the formula (I), which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.

  本发明涵盖了式(I)的化合物，适用于治疗与Vanin相关的疾病，以及制备这些化合物的方法、含有这些化合物的药物制剂，以及它们的使用方法。
• Heteroaromatic compounds as Vanin inhibitors
  申请人：Boehringer Ingelheim International GmbH

  公开号：US10364255B2

  公开（公告）日：2019-07-30

  The present invention encompasses compounds of the formula (I) wherein the groups A and B are defined herein, which are suitable for the treatment of diseases related to Vanin, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.

  本发明包括式 (I) 的化合物 其中基团 A 和 B 在本文中定义，适用于治疗与 Vanin 相关的疾病，以及制造这些化合物的工艺、含有这些化合物的药物制剂及其使用方法。
• [EN] NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM<br/>[FR] ANALOGUES DE NAPHTYLPYRIMIDINE, NAPHTYLPYRAZINE ET NAPHTYLPYRIDAZINE ET LEUR UTILISATION COMME AGONISTES DU SYSTÈME DE COMMUNICATION CELLULAIRE WNT-BÊTA-CATÉNINE
  申请人：WYETH CORP

  公开号：WO2009026319A1

  公开（公告）日：2009-02-26

  The present invention relates to naphthylpyrimidine analogs, methods of making naphthylpyrimidine analogs, compositions comprising a naphthylpyrimidine analog, and methods for treating canonical Wnt-[beta-symbol]-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of a naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analog.
• [EN] NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM<br/>[FR] ANALOGUES DE LA NAPHTHYLPYRIMIDINE, DE LA NAPHTHYLPYRAZINE ET DE LA NAPHTHYLPYRIDAZINE ET LEUR UTILISATION EN TANT QU'AGONISTES DU SYSTÈME DE MESSAGERIE CELLULAIRE WNT-BÊTA-CATÉNINE
  申请人：WYETH CORP

  公开号：WO2009026326A1

  公开（公告）日：2009-02-26

  The present invention relates to naphthylpyrimidine analogs, methods of making naphthylpyrimidine analogs, compositions comprising a naphthylpyrimidine analog, and methods for treating canonical Wnt-[beta-symbol]-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of a naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analog.