(2R,3R)-2-hydroxy-3-{[1-(2'-isobutyrylsulfamoylbiphenyl-4-ylmethyl)-5-propyl-1H-pyrazole-3-carbonyl]amino}-4-phenylbutyric acid | 1260232-05-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,3R)-2-hydroxy-3-{[1-(2'-isobutyrylsulfamoylbiphenyl-4-ylmethyl)-5-propyl-1H-pyrazole-3-carbonyl]amino}-4-phenylbutyric acid
• 英文别名: (2R,3R)-2-hydroxy-3-[[1-[[4-[2-(2-methylpropanoylsulfamoyl)phenyl]phenyl]methyl]-5-propylpyrazole-3-carbonyl]amino]-4-phenylbutanoic acid
• CAS: 1260232-05-0
• 化学式: C₃₄H₃₈N₄O₇S
• 分子量: 646.764
• InChiKey: LEGMITCGBHLXRN-GRKNLSHJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  46
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  176
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS
  申请人：Blair Brooke

  公开号：US20110009409A1

  公开（公告）日：2011-01-13

  In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R 3 , R 4 and R 5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT 1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

  在一个方面，该发明涉及具有以下结构式的化合物： 其中：Ar、Z、R3、R4和R5如规范中定义，或其药学上可接受的盐。这些化合物具有AT1受体拮抗活性和神经氨酸酶抑制活性。在另一个方面，该发明涉及包含这些化合物的药物组合物；使用这些化合物的方法；以及制备这些化合物的过程和中间体。
• Process for epoxidation and catalyst to be used therein
  申请人：BASF Aktiengesellschaft

  公开号：US20040054199A1

  公开（公告）日：2004-03-18

  The present invention relates to a process for treating a solid material containing at least one zeolite and being at least partly crystalline or treating a shaped body obtained from said solid material wherein said solid material or shaped body is brought in contact with a composition containing water after at least one of the following steps of an integrated process for producing a solid material or a shaped body containing at least one zeolite: (i) after step (II) of separating the at least partly crystalline solid material from its mother liquor or (ii) after step (S) of shaping said solid material into a shaped body or (iii) after a step (C) of calcining said solid material or said shaped body. The present invention furthermore relates to the solid material obtainable by the inventive process and the shaped body obtainable by the inventive process. The present invention finally relates to the use of the solid material or the shaped body as mentioned above as a catalyst in chemical reactions, in particular in reactions of compounds containing at least one C—C double bond with at least one hydroperoxide.

  本发明涉及一种处理含有至少一种沸石并且至少部分结晶的固体材料或处理从所述固体材料获得的成型体的方法，其中所述固体材料或成型体与含水的组合物接触，该组合物在生产含有至少一种沸石的固体材料或成型体的综合过程的以下步骤之一之后进行处理：(i)在将至少部分结晶的固体材料与其母液分离的步骤(II)之后，或(ii)在将所述固体材料成型为成型体的步骤(S)之后，或(iii)在焙烧所述固体材料或成型体的步骤(C)之后。本发明还涉及通过所述创新方法获得的固体材料和成型体。最后，本发明涉及将上述固体材料或成型体作为催化剂用于化学反应，特别是用于含有至少一种C—C双键和至少一种过氧化氢化合物的反应。
• IMPROVED MEANS AND METHODS TO TREAT DIABETES
  申请人：Eberhard Karls Universität Tübingen Medizinische Fakultät

  公开号：EP3689367A1

  公开（公告）日：2020-08-05

  The present application relates to a pharmaceutical composition for use in a method of treating diabetes in a human or animal subject in need thereof, to transplantation devices comprising the pharmaceutical composition of the present invention and to methods of treating diabetes using the pharmaceutical composition and transplantation device of the present invention.

  本申请涉及一种用于治疗有需要的人或动物糖尿病的方法的药物组合物，涉及包含本发明药物组合物的移植装置，还涉及使用本发明药物组合物和移植装置治疗糖尿病的方法。
• Catalyst for epoxidation reactions
  申请人：BASF Aktiengesellschaft

  公开号：US20040053772A1

  公开（公告）日：2004-03-18

  The present invention relates to the manufacture of solid materials or shaped bodies containing at least one zeolite and being at least partly crystalline. Furthermore, the present invention relates to the solid materials or shaped bodies as such and to the use of these materials for reactions of compounds having at least one C—C double bond with at least one hydroperoxide. Specifically, the present invention relates to a process for the manufacture of a solid material containing at least one zeolite and being at least partly crystalline, wherein the synthesis of the said solid material involves at least one partial step of contacting at least one transition metal oxide source with at least one epoxide or hydrolysate thereof prior to or during the at least partial crystallization of said solid material.

  本发明涉及含有至少一种沸石且至少部分结晶的固体材料或异型体的制造。此外，本发明还涉及此类固体材料或异型体，以及将这些材料用于具有至少一个 C-C 双键的化合物与至少一种过氧化氢的反应。具体而言，本发明涉及一种含有至少一种沸石且至少部分结晶的固体材料的制造工艺，其中所述固体材料的合成涉及至少一个部分步骤，即在所述固体材料至少部分结晶之前或期间，将至少一种过渡金属氧化物源与至少一种环氧化物或其水解物接触。
• IMPROVED CATALYST FOR EPOXIDATION REACTIONS
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：EP1549433A1

  公开（公告）日：2005-07-06