3-(Fluoromethyl)pyrrolidine hydrochloride | 1782410-86-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-(Fluoromethyl)pyrrolidine hydrochloride
• 英文别名: 3-(fluoromethyl)pyrrolidine;hydrochloride
• CAS: 1782410-86-9
• 化学式: C5H11ClFN
• 分子量: 139.6
• InChiKey: YJLVCUNOYYRZMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.99
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] DERIVATIVES OF 2,3-DIPHENYLCHROMENE USEFUL FOR THE TREATMENT OF CANCER<br/>[FR] DÉRIVÉS DE 2,3-DI(PHÉNYLCHROMÈNE) UTILES POUR LE TRAITEMENT DU CANCER
  申请人：HOFFMANN LA ROCHE

  公开号：WO2016097073A1

  公开（公告）日：2016-06-23

  Described herein are compounds that are estrogen receptor modulators of Formula I and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

  本文描述了一种具有公式I的雌激素受体调节剂及其立体异构体、互变异构体或药学上可接受的盐，并具有所述取代基和结构特征。还描述了包括所述化合物的药物组合物和药物，以及使用这种雌激素受体调节剂的方法，单独或与其他化合物结合，用于治疗与雌激素受体有关的疾病或症状。
• [EN] SUBSTITUTED BENZOTHIOPHENE ANALOGS AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS<br/>[FR] ANALOGUES DE BENZOTHIOPHÈNE SUBSTITUÉS EN TANT QU'AGENTS DE DÉGRADATION SÉLECTIFS DU RÉCEPTEUR D'ŒSTROGÈNES
  申请人：UNIV ILLINOIS

  公开号：WO2019157020A1

  公开（公告）日：2019-08-15

  In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

  在一个方面，该披露涉及与取代苯并噻吩类似物相关的内容，这些类似物可用作雌激素受体的选择性降解剂，制备方法，包含它们的药物组合物，以及治疗与雌激素受体相关的一个或多个临床病况的方法，如癌症，包括乳腺癌，或骨质疏松症。此摘要旨在用作在特定领域进行搜索的扫描工具，并不意在限制本披露。
• FLUORINATED ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
  申请人：SERAGON PHARMACEUTICALS, INC

  公开号：US20150005286A1

  公开（公告）日：2015-01-01

  Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

  本文描述了一些雌激素受体调节剂化合物。还描述了包括上述化合物的药物组成物和药物，以及使用这种雌激素受体调节剂的方法，单独或与其他化合物联合治疗介导或依赖于雌激素受体的疾病或病症。
• ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
  申请人：Genentech, Inc.

  公开号：US20160175284A1

  公开（公告）日：2016-06-23

  Described herein are compounds that are estrogen receptor modulators of Formula I: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

  本文描述的是一些具有公式I的雌激素受体调节剂，以及其立体异构体、互变异构体或药学上可接受的盐，以及所述的取代基和结构特征。还描述了包括上述化合物的药物组合物和药物，以及使用这些雌激素受体调节剂的方法，单独或与其他化合物结合，用于治疗介导或依赖于雌激素受体的疾病或症状。
• DERIVATIVES OF 2,3-DIPHENYLCHROMENE USEFUL FOR THE TREATMENT OF CANCER
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3233818A1

  公开（公告）日：2017-10-25