盐酸丙泮卡因 | 1679-79-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 盐酸丙泮卡因
• 英文名称: Propanocaine hydrochloride
• 英文别名: [3-(diethylamino)-1-phenylpropyl] benzoate;hydrochloride
• CAS: 1679-79-4
• 化学式: C20H26ClNO2
• 分子量: 347.9
• InChiKey: BTEONAMWIGDTPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.74
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] DERMAL COMPOSITIONS CONTAINING UNNATURAL HYGROSCOPIC AMINO ACIDS<br/>[FR] COMPOSITIONS DERMATOLOGIQUES CONTENANT DES AMINOACIDES HYGROSCOPIQUES NON NATURELS
  申请人：MEDPHARM LTD

  公开号：WO2014072747A1

  公开（公告）日：2014-05-15

  Unnatural, hygroscopic amino acids are useful to enhance the moisture retention and uptake properties of skin. In particular, such amino acids are N-hydroxyserine, N- hydroxyglycine, L-homoserine,alpha-hydroxyglycine, 2-(aminooxy) -2-hydroxyacetic acid, 2-hydroxy-2-(hydroxyamino) acetic acid, 2- (aininooxy)acetic acid, and combinations thereof.

  不自然的、亲水性的氨基酸对增强皮肤的保湿和吸湿性能是有用的。特别是，这些氨基酸包括N-羟基丝氨酸、N-羟基甘氨酸、L-同丝氨酸、α-羟基甘氨酸、2-(氨氧基)-2-羟基乙酸、2-羟基-2-(羟氨基)乙酸、2-(氨氧基)乙酸，以及它们的组合。
• DERMAL COMPOSITIONS CONTAINING UNNATURAL HYGROSCOPIC AMINO ACIDS
  申请人：MEDPHARM LIMITED

  公开号：US20150328109A1

  公开（公告）日：2015-11-19

  Unnatural, hygroscopic amino acids are useful to enhance the moisture retention and uptake properties of skin. In particular, such amino acids are N-hydroxyserine, N-hydroxyglycine, L-homoserine, alpha-hydroxyglycine, 2-(aminooxy)-2-hydroxyacetic acid, 2-hydroxy-2-(hydroxyamino) acetic acid, 2-(aininooxy)acetic acid, and combinations thereof.

  不自然的、亲水性的氨基酸对于增强皮肤的保湿性和吸水性非常有用。特别是，这些氨基酸包括N-羟基丝氨酸、N-羟基甘氨酸、L-脯氨酸、α-羟基甘氨酸、2-(氨氧基)-2-羟基乙酸、2-羟基-2-(羟胺基)乙酸、2-(氨氧基)乙酸和它们的组合。
• Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0386960A2

  公开（公告）日：1990-09-12

  There is provided a pharmaceutical composition which comprises an aqueous vehicle, a compound having reversible thermosetting gel properties and a compound having film-forming properties. Depending on the relative proportions of these components, the composition can be adapted to function either as a vehicle for delivering pharmacologically or diagnostically active compounds to a human or animal patient and/or as a wound dressing composition.

  本发明提供了一种药物组合物，它包括一种水性载体、一种具有可逆热固性凝胶特性的化合物和一种具有成膜特性的化合物。根据这些成分的相对比例，该组合物既可用作向人类或动物患者输送药理或诊断活性化合物的载体，也可用作伤口敷料组合物。
• Materials useful in human and veterinary medicine
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0481600A2

  公开（公告）日：1992-04-22

  There is provided a solid material useful in medicine, especially a film material for use as a wound dressing or as a drug delivery vehicle, which comprises a molecular mixture of (a) a compound which has film-forming properties, for example hydroxyethylcellulose, hydroxypropylmethylcellulose or polyvinyl alcohol, and (b) a polyoxyethylene-polyoxypropylene block copolymer or a tetrasubstituted derivative of ethylene-diamine in which the substituents are block copolymers of polyoxyethylene-polyoxypropylene, as a modifier. The molecular mixture may be formed, for example, by evaporating a solution of the two components (a) and (b) in a solvent, or by cooling a liquid composition comprising at least one of components (a) and (b) in molten form from an elevated temperature.

  本发明提供了一种用于医药的固体材料，特别是一种用作伤口敷料或给药载体的薄膜材料，它包括以下物质的分子混合物：(a) 一种具有成膜特性的化合物，例如羟乙基纤维素、羟丙基甲基纤维素或聚乙烯醇，以及(b) 聚氧乙烯-聚氧丙烯嵌段共聚物或乙烯-二甲基纤维素的四代衍生物、(b) 作为改性剂的聚氧乙烯-聚氧丙烯嵌段共聚物或乙二胺的四取代衍生物，其中的取代基为聚氧乙烯-聚氧丙烯嵌段共聚物。分子混合物可通过以下方式形成：例如，蒸发两种组分（a）和（b）在溶剂中的溶液，或从高温下冷却包含至少一种熔融状态组分（a）和（b）的液体组合物。
• Dermal drug delivery system
  申请人：Brown Barry Marc

  公开号：US20060130266A1

  公开（公告）日：2006-06-22

  A device for brushing the skin prior to applying a topical preparation of a drug enhances the permeability of the stratum corneum to the drug.

  一种用于在局部使用药物制剂之前刷洗皮肤的装置，可增强角质层对药物的渗透性。