盐酸二氢萘酸盐 | 76005-58-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 盐酸二氢萘酸盐
• 英文名称: Dimenhydrinate hydrochloride
• 英文别名: 2-benzhydryloxy-N,N-dimethylethanamine;8-chloro-1,3-dimethyl-7H-purine-2,6-dione;hydrochloride
• CAS: 76005-58-8
• 化学式: C24H29Cl2N5O3
• 分子量: 506.4
• InChiKey: XBELCFNAGSCRNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.39
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  81.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NARINGIN AND LEVOCETIRIZINE HYDROCHLORIDE PHARMACEUTICAL COMPOSITION AND PREPARATION THEREOF
  申请人：Sun Yat-Sen University

  公开号：EP3069723A1

  公开（公告）日：2016-09-21

  A naringin composition and preparations thereof are provided. The pharmaceutical composition comprises naringin and levocetirizine hydrochloride, and preferably, 27.5-275 mg of naringin and 1.25-12.5 mg of levocetirizine hydrochloride, where the preferred weight ratio of naringin to levocetirizine hydrochloride is 20:1. The pharmaceutical composition has good curative effects on cough and sputum production originating from various causes and on cough variant asthma. The efficacy of the pharmaceutical composition is obviously superior to that of naringin or levocetirizine hydrochloride that is used alone.

  提供了一种柚皮苷组合物及其制剂。该药物组合物由柚皮苷和盐酸左西替利嗪组成，优选柚皮苷27.5-275毫克，盐酸左西替利嗪1.25-12.5毫克，其中柚皮苷与盐酸左西替利嗪的重量比优选为20:1。该药物组合物对各种原因引起的咳嗽、咳痰以及咳嗽变异性哮喘有良好的疗效。该药物组合物的疗效明显优于单独使用柚皮苷或盐酸左西替利嗪。
• Compositions and methods for ophthalmic and/or other applications
  申请人：The Johns Hopkins University

  公开号：US10945948B2

  公开（公告）日：2021-03-16

  Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.

  本文提供了有助于颗粒在粘液中传输的颗粒、组合物和方法。这些微粒、组合物和方法在某些情况下可用于眼科和/或其他应用。在某些实施方案中，这些组合物和方法可能涉及颗粒表面涂层的改性，例如水溶性较低的药剂颗粒。此类组合物和方法可用于实现药剂颗粒通过体内粘液屏障的高效运输，应用范围广泛，包括药物输送、成像和诊断应用。在某些实施方案中，包括此类微粒的药物组合物非常适合眼科应用，可用于将药剂输送到眼球前部和/或眼球后部。
• PHARMACEUTICAL COMPOSITION COMPRISING NARINGIN AND LEVOCETIRIZINE HYDROCHLORIDE, AND PREPARATIONS THEREOF
  申请人：Sun Yat-sen University

  公开号：US20160303156A1

  公开（公告）日：2016-10-20

  A naringin composition and preparations thereof are provided. The pharmaceutical composition comprises naringin and levocetirizine hydrochloride, and preferably, 27.5-275 mg of naringin and 1.25-12.5 mg of levocetirizine hydrochloride, where the preferred weight ratio of naringin to levocetirizine hydrochloride is 20:1. The pharmaceutical composition has good curative effects on cough and sputum production originating from various causes and on cough variant asthma. The efficacy of the pharmaceutical composition is obviously superior to that of naringin or levocetirizine hydrochloride that is used alone.
• COMPOSITIONS AND METHODS FOR OPHTHALMIC AND/OR OTHER APPLICATIONS
  申请人：The Johns Hopkins University

  公开号：US20200368154A1

  公开（公告）日：2020-11-26

  Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.
• US4895857A
  申请人：——

  公开号：US4895857A

  公开（公告）日：1990-01-23