NO-Dimethyl-N-(1-methyl-2-phenylethyl)hydroxylamin | 2205-03-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: NO-Dimethyl-N-(1-methyl-2-phenylethyl)hydroxylamin
• 英文别名: Methoxy methyl amphetamine；N-methoxy-N-methyl-1-phenylpropan-2-amine
• CAS: 2205-03-0
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: SSFGHISVFJMECH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] A NOVEL CONCEPT TO REDUCE LEFT ATRIAL PRESSURE IN SYSTOLIC AND DIASTOLIC HF PATIENTS TO TREAT PULMONARY EDEMA AND REDUCE HOSPITALIZATION RATES<br/>[FR] NOUVEAU CONCEPT POUR RÉDUIRE LA PRESSION AURICULAIRE GAUCHE CHEZ DES PATIENTS ATTEINTS D'INSUFFISANCE CARDIAQUE SYSTOLIQUE OU DIASTOLIQUE AFIN DE TRAITER UN ŒDÈME PULMONAIRE ET DE RÉDUIRE LES TAUX D'HOSPITALISATION
  申请人：BOSTON SCIENT SCIMED INC

  公开号：WO2016126921A1

  公开（公告）日：2016-08-11

  Devices provided herein can include implantable transseptal flow control components adapted to be implanted in an opening in a septal wall. In a closed configuration, the implantable transseptal flow control components provided herein prevent blood from flowing through the opening. In an open configuration, the implantable transseptal flow control components provided herein allow blood to flow from the left atrium to the right atrium. In a closed configuration, implantable transseptal flow control components provided herein can be configured such that blood does not stagnate at a location proximate to a left atrium flow control component side when the pressure differential is below a second predetermined threshold pressure value. Implantable transseptal flow control components provided herein can remain in a closed configuration when a pressure differential between the left atrium and the right atrium is less than a first non-zero predetermined threshold pressure value.