(3S,4R)-4-hydroxypyrrolidine-3-carboxylic acid | 1248566-13-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (3S,4R)-4-hydroxypyrrolidine-3-carboxylic acid
• CAS: 1248566-13-3
• 化学式: C₅H₉NO₃
• 分子量: 131.131
• InChiKey: YDQDOPAGBYQTJD-IMJSIDKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl (3S,4R)-4-acetoxypyrrolidine-3-carboxylate 在 水 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 以93%的产率得到(3S,4R)-4-hydroxypyrrolidine-3-carboxylic acid
  参考文献：
  名称：

  Syntheses of novel azasugar-containing mimics of heparan sulfate fragments as potential heparanase inhibitors

  摘要：

  A series of eight novel, highly modified mono-, di- and trisaccharide derivatives, each containing an iminoalditol moiety, has been synthesized in the quest for potential heparanase inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2010.05.032

文献信息

• Syntheses of novel azasugar-containing mimics of heparan sulfate fragments as potential heparanase inhibitors
  作者：Kirsty A. Allen、Rosemary L. Brown、Gillian Norris、Peter C. Tyler、Derek K. Watt、Olga V. Zubkova

  DOI：10.1016/j.carres.2010.05.032

  日期：2010.9

  A series of eight novel, highly modified mono-, di- and trisaccharide derivatives, each containing an iminoalditol moiety, has been synthesized in the quest for potential heparanase inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.