5-dec-1-yn-1-yl-2',3',5'-tri-O-benzoyl-2'-C-methyluridine | 1203461-97-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-dec-1-yn-1-yl-2',3',5'-tri-O-benzoyl-2'-C-methyluridine
• 英文别名: [(2R,3R,4R,5R)-3,4-dibenzoyloxy-5-(5-dec-1-ynyl-2,4-dioxopyrimidin-1-yl)-4-methyloxolan-2-yl]methyl benzoate
• CAS: 1203461-97-5
• 化学式: C₄₁H₄₂N₂O₉
• 分子量: 706.792
• InChiKey: IYJBSMIAQSBJFT-YAGSZOAASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  52
• 可旋转键数：
  18
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  138
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  5-dec-1-yn-1-yl-2',3',5'-tri-O-benzoyl-2'-C-methyluridine 在 甲醇 、 氨 作用下， 反应 24.0h， 生成 5-dec-1-yn-1-yl-2'-C-methyluridine
  参考文献：
  名称：

  Synthesis and Antiviral Evaluation of 2′-C-Methyl Analogues of 5-Alkynyl- and 6-Alkylfurano- and Pyrrolo[2,3-d]Pyrimidine Ribonucleosides

  摘要：

  A series of novel 2'-C-methylribonucleosides, involving 5-iodo and 5-alkynyl uridine analogues as well as related bicyclic furano- and pyrrolo[2,3-d]pyrimidinone compounds, has been synthesized and evaluated for their inhibitory effect on replication of the hepatitis C virus (HCV). The new nucleoside analogues did not show meaningful anti-HCV activity.

  DOI：

  10.1080/15257770903128870
• 作为产物：
  描述：

  1-癸炔 、 tri-O-benzoyl-5-iodo-2'-C-methyluridine 在 copper(l) iodide 、 四(三苯基膦)钯 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 19.0h， 生成 5-dec-1-yn-1-yl-2',3',5'-tri-O-benzoyl-2'-C-methyluridine
  参考文献：
  名称：

  Synthesis and Antiviral Evaluation of 2′-C-Methyl Analogues of 5-Alkynyl- and 6-Alkylfurano- and Pyrrolo[2,3-d]Pyrimidine Ribonucleosides

  摘要：

  A series of novel 2'-C-methylribonucleosides, involving 5-iodo and 5-alkynyl uridine analogues as well as related bicyclic furano- and pyrrolo[2,3-d]pyrimidinone compounds, has been synthesized and evaluated for their inhibitory effect on replication of the hepatitis C virus (HCV). The new nucleoside analogues did not show meaningful anti-HCV activity.

  DOI：

  10.1080/15257770903128870

文献信息

• Synthesis and Antiviral Evaluation of 2′-C-Methyl Analogues of 5-Alkynyl- and 6-Alkylfurano- and Pyrrolo[2,3-<i>d</i>]Pyrimidine Ribonucleosides
  作者：Piotr Januszczyk、Joanna Fogt、Jerzy Boryski、Kunisuke Izawa、Tomoyuki Onishi、Johan Neyts、Erik De Clercq

  DOI：10.1080/15257770903128870

  日期：2009.8.11

  A series of novel 2'-C-methylribonucleosides, involving 5-iodo and 5-alkynyl uridine analogues as well as related bicyclic furano- and pyrrolo[2,3-d]pyrimidinone compounds, has been synthesized and evaluated for their inhibitory effect on replication of the hepatitis C virus (HCV). The new nucleoside analogues did not show meaningful anti-HCV activity.