(R)-6-(2,3-dihydroxypropyl)-3-fluoro-4-(2-fluoro-4-iodophenylamino)-1-methyl-1,6-naphthyridine-2,5(1H,6H)-dione | 1189047-55-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-6-(2,3-dihydroxypropyl)-3-fluoro-4-(2-fluoro-4-iodophenylamino)-1-methyl-1,6-naphthyridine-2,5(1H,6H)-dione
• 英文别名: 6-[(2R)-2,3-dihydroxypropyl]-3-fluoro-4-(2-fluoro-4-iodoanilino)-1-methyl-1,6-naphthyridine-2,5-dione
• CAS: 1189047-55-9
• 化学式: C₁₈H₁₆F₂IN₃O₄
• 分子量: 503.244
• InChiKey: PZTIVKPVQXYRKL-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  93.1
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• MAPK/ERK KINASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：Dong Qing

  公开号：US20090246198A1

  公开（公告）日：2009-10-01

  Compounds of the following formula are provided: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

  提供以下公式的化合物：其中变量的定义如本文所述。还提供包含这些化合物的药物组合物、试剂盒和制造品；用于制备这些化合物的方法和中间体；以及使用这些化合物的方法。
• [EN] MAPK/ERK KINASE INHIBITORS AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS DE KINASES MAPK/ERK ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2009146034A2

  公开（公告）日：2009-12-03

  Compounds of the following formula are provided: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.