17α-4'-hydroxyphenoxylmethyl-4-methylestra-1,3,5(10),-tetraene-1,17β-diol | 246021-17-0

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 17α-4'-hydroxyphenoxylmethyl-4-methylestra-1,3,5(10),-tetraene-1,17β-diol
• 英文别名: 17α-4'-hydroxy-phenoxymethyl-4-methyl-estra-1,3,5(10),6-tetraen-1,17β-diol；17α-4'-hydroxyphenoxymethyl-4-methylestra-1,3,5(10),6-tetraene-1,17β-diol；(8S,9S,13S,14S,17S)-17-[(4-hydroxyphenoxy)methyl]-4,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthrene-1,17-diol
• CAS: 246021-17-0
• 化学式: C₂₆H₃₀O₄
• 分子量: 406.522
• InChiKey: AQBQDNVPKOXWFU-HCQBBNJVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Non-estrogenic estradiol derivative compounds with antioxidative activity
  申请人：——

  公开号：US20020065258A1

  公开（公告）日：2002-05-30

  New non-estrogenic derivative compounds of estradiol, which have no estrogenic activity and comparatively high anti-oxidative activity, are disclosed. These new non-estrogenic derivative compounds are potentially useful as non-estrogenic antioxidants, especially for administration in post-menopausal women and in men. The compounds of the invention can also inhibit aromatase and sulfatase.

  本研究公开了雌二醇的新型非雌激素衍生物化合物，它们没有雌激素活性，但具有相对较高的抗氧化活性。这些新型非雌激素衍生物化合物可作为非雌激素抗氧化剂，尤其适用于绝经后妇女和男性。本发明的化合物还可以抑制芳香化酶和硫酸化酶。
• Pharmaceutical preparations for treating side effects during and/or after GnRHa therapy
  申请人：——

  公开号：US20020065260A1

  公开（公告）日：2002-05-30

  The pharmaceutical preparations for treating side effects, such as hot flashes, prostate enlargement and gynecomastia, during and/or after treatment with analogs or antagonists of gonadotropin-releasing hormone (GnRHa therapy) contain an effective amount of a chemically modified derivative of 17&agr;-estradiol, a chemically modified derivative of 17&bgr;-estradiol and/or a chemical modified derivative of estriol. Pharmaceutical preparations containing 14&agr;,15&agr;-methylene-1,3,5(10),8-tetraene-3,17&agr;-diol are particularly preferred.

  用于治疗促性腺激素释放激素类似物或拮抗剂（GnRHa疗法）治疗期间和/或治疗后的副作用，如潮热、前列腺增生和妇科炎症的药物制剂含有有效量的17&agr;-雌二醇的化学修饰衍生物、17&bgr;-雌二醇的化学修饰衍生物和/或雌三醇的化学修饰衍生物。特别优选含有14&agr;,15&agr;-亚甲基-1,3,5(10),8-四烯-3,17&agr;-二醇的药物制剂。
• NICHTESTROGENE DERIVATE DES ESTRADIOLS MIT ANTIOXIDATIVER AKTIVITÄT
  申请人：Jenapharm GmbH & Co. KG

  公开号：EP0986573B1

  公开（公告）日：2002-10-09
• US6436917B1
  申请人：——

  公开号：US6436917B1

  公开（公告）日：2002-08-20
• US6689768B2
  申请人：——

  公开号：US6689768B2

  公开（公告）日：2004-02-10