Methyl 3,5-diisopropylbenzoate | 1121584-99-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 3,5-diisopropylbenzoate
• 英文别名: methyl 3,5-di(propan-2-yl)benzoate
• CAS: 1121584-99-3
• 化学式: C₁₄H₂₀O₂
• 分子量: 220.31
• InChiKey: KMVYMCVCCGFYOC-UHFFFAOYSA-N

物化性质

• 沸点：
  287.6±29.0 °C(Predicted)
• 密度：
  0.968±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] SIMPLE MANUFACTURING AND PURIFICATION TECHNOLOGY FOR HIGH PURITY PROPOFOL<br/>[FR] TECHNOLOGIE DE PRODUCTION ET DE PURIFICATION SIMPLE POUR PROPOFOL DE HAUTE PURETÉ
  申请人：CHODANKAR NANDKUMAR

  公开号：WO2021156776A1

  公开（公告）日：2021-08-12

  A process for manufacturing Pure Propofol with a purity of more than 99.90% is disclosed, said process comprising dissolving Crude Propofol in a solvent in which it is soluble to form a solution, treating the solution with aqueous alkali to form an aqueous alkali layer and a solvent layer, separating the aqueous alkali layer from the solvent layer using a phase separation technique, distilling off the solvent from the solvent layer, and distilling a residue of the solvent containing Propofol using steam or boiling water in a presence of dilute alkali and antioxidant like metabisulfite, under normal pressure or mild vacuum.

  本发明揭示了一种制造纯度高于99.90％的纯丙泊酚的工艺，该工艺包括将粗丙泊酚溶解在其可溶的溶剂中形成溶液，用水性碱处理溶液以形成水性碱层和溶剂层，使用相分离技术将水性碱层与溶剂层分离，从溶剂层中蒸馏出溶剂，并在常压或轻度真空下，使用蒸汽或沸水在稀碱和亚硫酸盐等抗氧化剂的存在下，蒸馏含有丙泊酚的溶剂残留物。
• SIMPLE MANUFACTURING AND PURIFICATION TECHNOLOGY FOR HIGH PURITY PROPOFOL
  申请人：Chodankar, Nandkumar

  公开号：EP4100384A1

  公开（公告）日：2022-12-14
• Glycopeptide Antibiotic Monomer Derivatives
  申请人：Arimoto Hirokazu

  公开号：US20080097078A1

  公开（公告）日：2008-04-24

  Novel glycopeptide antibiotic derivatives. These derivatives are represented by the formula (aglycon part of glycopeptide antibiotic derivative)-(Sac-NH)—R A [wherein (aglycon part of glycopeptide antibiotic derivative) is the part formed by removing the sugar part from a known glycopeptide antibiotic derivative; (Sac-NH) part is an amino sugar part or a sugar chain part containing an amino sugar; and R A represents, e.g., the formula —X 1 —Ar 1 —X 2 —Y—X 3 —Ar 2 (wherein X 1 , X 2 , and X 3 each represents 1) a single bond or 2) a heteroatom or heteroatom-containing group selected from the group consisting of —N═, ═N—, —NR 1 —, —O—, etc.; Y represents —NR 2 CO— or —CONR 2 — (wherein R 2 represents hydrogen or lower alkyl), etc.)]. These derivatives have antibacterial activity against vancomycin-resistant bacteria.
• US8778874B2
  申请人：——

  公开号：US8778874B2

  公开（公告）日：2014-07-15