4'-(2-hydroxy-ethoxy)-biphenyl-4-carbaldehyde | 473257-32-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-(2-hydroxy-ethoxy)-biphenyl-4-carbaldehyde
• 英文别名: 4-[4-(2-Hydroxyethoxy)phenyl]benzaldehyde
• CAS: 473257-32-8
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: GDIOYGOLHAFDSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SUBSTITUTED AMINO-AZA-CYCLOALKANES USEFUL AGAINST MALARIA
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP1322612A1

  公开（公告）日：2003-07-02
• SUBSTITUTED ALKYLDIAMINES AS INHIBITORS OF PLASMEPSIN OR RELATED PROTEASES
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP1335899A2

  公开（公告）日：2003-08-20
• [EN] SUBSTITUTED AMINO-AZA-CYCLOALKANES USEFUL AGAINST MALARIA<br/>[FR] AMINO-AZA-CYCLOALCANES SUBSTITUES UTILES CONTRE LA MALARIA
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2002024649A1

  公开（公告）日：2002-03-28

  The invention relates to novel compounds which are substituted amino-aza-cycloalkane derivatives of the general formula I. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of general formula I and especially their use as inhibitors of the plasmodium falciparum protease plasmepsin II or related aspartic proteases.
• [EN] SUBSTITUTED ALKYLDIAMINES<br/>[FR] ALKYLDIAMINES SUBSTITUES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2002038534A2

  公开（公告）日：2002-05-16

  The invention relates to novel compounds which are substituted alkyldiamino derivatives of formula (I). The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of formula (I) and especially their use as inhibitors of the plasmodium falciparum protease plasmepsin II or related aspartic proteases.
• [EN] NOVEL AMINO-AZA-CYCLOHEXANES<br/>[FR] AMINO-AZA-CYCLOHEXANES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2002083641A2

  公开（公告）日：2002-10-24

  The invention relates to novel compounds which are substituted amino-aza-cyclohexane derivatives of the general formula (I). The invention also concerns related aspects including pharmaceutical compositions containing one or more compounds of the general formula I and their use as medicaments for the treatment of protozoal infections, especially malaria.