morpholine-4-carboxylic acid 4-phenoxy-phenyl ester | 136100-13-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: morpholine-4-carboxylic acid 4-phenoxy-phenyl ester
• 英文别名: (4-Phenoxyphenyl) morpholine-4-carboxylate
• CAS: 136100-13-5
• 化学式: C₁₇H₁₇NO₄
• 分子量: 299.326
• InChiKey: BPGPFGAELDAFMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
  申请人：——

  公开号：US20030166644A1

  公开（公告）日：2003-09-04

  Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.

  使用化合物抑制激素敏感性脂肪酶，包括这些化合物的药物组合物，使用这些化合物和组合物的治疗方法，以及新化合物。目前的化合物是激素敏感性脂肪酶的抑制剂，可能在治疗和/或预防需要降低激素敏感性脂肪酶活性的医学疾病中有用。
• Use of compounds for decreasing activity of hormone-sensitive
  申请人：——

  公开号：US20030166690A1

  公开（公告）日：2003-09-04

  Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.

  使用化合物来抑制激素敏感性脂肪酶，包括这些化合物的制药组合物，使用这些化合物和组合物的治疗方法，以及新颖的化合物。这些化合物是激素敏感性脂肪酶的抑制剂，可用于治疗和/或预防需要降低激素敏感性脂肪酶活性的医学疾病。
• Cholesterol ester hydrolase inhibitors
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0428385A1

  公开（公告）日：1991-05-22

  The compounds of the formula: in which R¹ is alkyl of 4 or more carbon atoms, cycloalkyl, 1-adamantyl, 2-adamantyl, 3-noradamantyl, 3-methyl-1-adamantyl, 1-fluorenyl, 9-fluorenyl, cycloalkylalkyl, phenyl, substituted phenyl, alkyl, alkoxy, halo, nitro, cyano or trifluoromethyl, phenylalkyl or substituted phenylalkyl, where the substituent on the benzene ring is alkyl, alkoxy, halo, nitro, cyano, trifluoromethyl or phenyl; R² is hydrogen, alkyl or R¹ taken with R² and the nitrogen atom to which they are attached form a heterocyclic moiety of the formula: wherein in which R⁷ is hydrogen, alkyl, hydroxy, alkanoyloxy, hydroxyalkyl, hydroxycarbonyl, alkoxycarbonyl, phenyl or substituted phenyl, in which the substituent is alkyl, alkoxy, halo, nitro, cyano, haloalkyl, perhaloalkyl or dialkylaminoalkyl; R⁸ is hydrogen or alkyl or R⁷ and R⁸ taken together are polymethylene; R⁹ is hydrogen, alkyl, phenyl or substituted phenyl, in which the substituent is alkyl, alkoxy, halo, nitro, cyano or perhaloalkyl; R¹⁰ is hydrogen, alkyl or gemdialkyl; n is one of the integers 0, 1 or 2; and R³, R⁴, R⁵ and R⁶ are, independently, hydrogen, alkyl, alkoxy, halo, nitro, cyano or perhaloalkyl, alkoxycarbonyl or hydroxycarbonyl; and when X is -NR⁹- or R⁷ is an amino alkyl group, a pharmaceutically acceptable salt thereof; useful as inhibitors of cholesterol ester hydrolase.

  式中的化合物 其中 R¹ 为 4 个或 4 个以上碳原子的烷基、环烷基、1-金刚烷基、2-金刚烷基、3-正金刚烷基、3-甲基-1-金刚烷基、1-芴基、9-芴基、环烷基、苯基、取代苯基、烷氧基、卤代、硝基、氰基或三氟甲基、苯基烷基或取代苯基烷基，其中苯环上的取代基为烷氧基、卤代、硝基、氰基或三氟甲基、烷基、烷氧基、卤代、硝基、氰基或三氟甲基、苯基烷基或取代苯基烷基，其中苯环上的取代基为烷基、烷氧基、卤代、硝基、氰基、三氟甲基或苯基；R² 是氢、烷基或 R¹ 与 R² 及其所连接的氮原子形成式中的杂环分子： 其中 其中 R⁷ 是氢、烷基、羟基、烷酰氧基、羟基烷基、羟基羰基、烷氧基羰基、苯基或取代苯基，其中取代基是烷基、烷氧基、卤代、硝基、氰基、卤代烷基、全卤代烷基或二烷基氨基烷基；R⁸ 是氢或烷基，或 R⁷ 和 R⁸ 合在一起是聚亚甲基；R⁹ 是氢、烷基、苯基或取代苯基，其中取代基是烷基、烷氧基、卤代、硝基、氰基或高卤烷基；R¹⁰ 是氢、烷基或二烷基；n 是整数 0、1 或 2 之一；以及 R³、R⁴、R⁵ 和 R⁶ 独立地是氢、烷基、烷氧基、卤代、硝基、氰基或高卤烷基、烷氧基羰基或羟基羰基；当 X 为-NR⁹- 或 R⁷ 为氨基烷基时，其药学上可接受的盐；可用作胆固醇酯水解酶的抑制剂。
• COMPOSITIONS FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE
  申请人：NOVO NORDISK A/S

  公开号：EP1458375A2

  公开（公告）日：2004-09-22
• COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE
  申请人：NOVO NORDISK A/S

  公开号：EP1458374A2

  公开（公告）日：2004-09-22