N6-[(Benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-L-lysine | 1037593-45-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N6-[(Benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-L-lysine
• 英文别名: (2S)-2-[(4-bromobenzoyl)amino]-6-(phenylmethoxycarbonylamino)hexanoic acid
• CAS: 1037593-45-5
• 化学式: C₂₁H₂₃BrN₂O₅
• 分子量: 463.328
• InChiKey: NMDSITQGUBFCRH-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl N6-((benzyloxy)carbonyl)-N2-(4-bromobenzoyl)-L-lysinate 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 以83%的产率得到N6-[(Benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-L-lysine
  参考文献：
  名称：

  Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors

  摘要：

  A series of novel L-lysine derivatives were designed, synthesized, and assayed for their inhibitory activities on amino-peptidase N(APN)/CD13 and matrix metalloproteinase-2 (MMP-2). The preliminary biological test showed that most of the compounds displayed a high inhibitory activity against MMP-2 and a low activity against APN except compound B6 which exhibited good potency (IC50 = 13.2 mu M) similar with APN inhibitor Bestatin (IC50 = 15.5 mu M), and could be used as lead compound in the future. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.04.012

文献信息

• Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors
  作者：Qiang Wang、Maoying Chen、Huawei Zhu、Jie Zhang、Hao Fang、Binghe Wang、Wenfang Xu

  DOI：10.1016/j.bmc.2008.04.012

  日期：2008.5

  A series of novel L-lysine derivatives were designed, synthesized, and assayed for their inhibitory activities on amino-peptidase N(APN)/CD13 and matrix metalloproteinase-2 (MMP-2). The preliminary biological test showed that most of the compounds displayed a high inhibitory activity against MMP-2 and a low activity against APN except compound B6 which exhibited good potency (IC50 = 13.2 mu M) similar with APN inhibitor Bestatin (IC50 = 15.5 mu M), and could be used as lead compound in the future. (C) 2008 Elsevier Ltd. All rights reserved.