(R)-(-)-5-[(4'-chloro-1,1'-biphenyl)-4-yl]-5-methyl-3,4-dihydroxy-2(5H)-furanone | 351197-16-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-(-)-5-[(4'-chloro-1,1'-biphenyl)-4-yl]-5-methyl-3,4-dihydroxy-2(5H)-furanone
• 英文别名: (5R)-5-[4-(4-chlorophenyl)phenyl]-3,4-dihydroxy-5-methylfuran-2-one
• CAS: 351197-16-5
• 化学式: C₁₇H₁₃ClO₄
• 分子量: 316.741
• InChiKey: MKRMPLQVPMOCGU-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• METHODS FOR RESOLVING RACEMIC MIXTURES OF 5-SUBSTITUTED 4-HYDROXY-2-FURANONES
  申请人：OXIS Isle of Man, Limited

  公开号：EP1246811A1

  公开（公告）日：2002-10-09
• US6265436B1
  申请人：——

  公开号：US6265436B1

  公开（公告）日：2001-07-24
• [EN] METHODS FOR RESOLVING RACEMIC MIXTURES OF 5-SUBSTITUTED 4-HYDROXY-2-FURANONES<br/>[FR] PROCEDES POUR LA RESOLUTION DES MELANGES RACEMIQUES DE 4-HYDROXY-2-FURANONES A SUBSTITUTION EN 5
  申请人：OXIS ISLE OF MAN LTD

  公开号：WO2001049671A1

  公开（公告）日：2001-07-12

  This invention affords a solution tO the technical problem of obtaining one or both enantiomers of 5-substituted 4-hydroxyfuran-2-ones in pure form by resolution with enantiomerically pure bases. Racemic mixtures of 5-substituted 4-hydroxy-2(5H)-furanones, including 5-substitited and 5,5-disubstituted, 4-hydroxy and 3,4-dihydroxy furanones are separated into pure enantiomers by crystallization with an enantiomerically pure base, such as cinchonidine. In specific solvent mixtures, for example, 95 % ethanol, the diastereomerically pure salt of one enantiomer crystallizeS. The enantiomerically pure furanone can then be obtained simply by filtration and treatment of the salt with an acid, for example, trifluoracetic acid, followed by precipitation with water, filtration and drying. Moreover, the other enantiomer may be equally obtained in pure form by evaporation of the mother liquor, followed by the same treament of the salt as described before.