2.4-Bis-<4-cyan-anilino>-1.3.5-triazin | 109567-04-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2.4-Bis-<4-cyan-anilino>-1.3.5-triazin
• 英文别名: 4,4'-[1,3,5]triazine-2,4-diyldiamino-bis-benzonitrile；4-[[4-(4-Cyanoanilino)-1,3,5-triazin-2-yl]amino]benzonitrile
• CAS: 109567-04-6
• 化学式: C₁₇H₁₁N₇
• 分子量: 313.321
• InChiKey: ODDWRIOTFQBJIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Microbicidal pyrimidine or triazine for preventing sexual hiv transmission
  申请人：Van Roey Marcel Jens

  公开号：US20060166943A1

  公开（公告）日：2006-07-27

  A present invention concerns the microbicidal activity of certain pyrimidine or triazine containing non-nucleoside reverse transcriptase inhibitors. The compounds of the present invention inhibit the systemic infection of a human being with HIV, in particular, the present compounds prevent sexual HIV transmission in humans.

  本发明涉及某些含嘧啶或三嗪的非核苷类逆转录酶抑制剂的杀微生物活性。本发明的化合物可抑制人类全身感染艾滋病毒，特别是本发明的化合物可防止艾滋病毒在人体内的性传播。
• MICROBICIDAL PYRIMIDINE OR TRIAZINE FOR PREVENTING SEXUAL HIV TRANSMISSION
  申请人：Tibotec Pharmaceuticals Ltd.

  公开号：EP1505980A1

  公开（公告）日：2005-02-16
• PLATINUM-CATALYZED INTRAVAGINAL RINGS
  申请人：Malcolm Karl

  公开号：US20140056961A1

  公开（公告）日：2014-02-27

  The present invention provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of an antimicrobial compound, e.g., Dapivirine, to a human. The intravaginal rings of the invention address previous stability issues by utilizing a platinum catalyst (e.g., in the form of a platinum-siloxane complex) for the cross-linking reaction. The vaginal rings surprisingly achieve relatively high and steady release rates in vivo with a matrix ring containing a relatively small loading dose. While the matrix rings of the present invention have in vivo the steady release rates associated with reservoir rings, they are easier and less expensive to manufacture. The present invention also provides methods of blocking DNA polymerization by an HIV reverse transcriptase enzyme, methods of preventing HIV infection in a female human, methods of treating HIV infection in a female human, and methods of preparing platinum-catalyzed intravaginal rings.
• Microbicidal Pyrimidine Or Triazine Containing Compounds
  申请人：JANSSEN SCIENCES IRELAND UC

  公开号：US20170100399A1

  公开（公告）日：2017-04-13

  The present invention concerns the microbicidal activity of certain pyrimidine or triazine containing non-nucleoside reverse transcriptase inhibitors. The compounds of the present invention inhibit the systemic infection of a human being with HIV, in particular, the present compounds prevent sexual HIV transmission in humans,
• Microbicidal Pyrimidine or Triazine Containing Compounds
  申请人：Janssen Sciences Ireland UC

  公开号：US20200345733A1

  公开（公告）日：2020-11-05

  The present invention concerns the microbicidal activity of certain pyrimidine or triazine containing non-nucleoside reverse transcriptase inhibitors. The compounds of the present invention inhibit the systemic infection of a human being with HIV, in particular, the present compounds prevent sexual HIV transmission in humans.