1,3-Bis(ethoxy)-1,3-bis(oxo)-2-propyl 3,5-bis(acetylamino)-2,4,6-triiodobenzoate | 153339-44-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-Bis(ethoxy)-1,3-bis(oxo)-2-propyl 3,5-bis(acetylamino)-2,4,6-triiodobenzoate
• 英文别名: diethyl 2-(3,5-bis (acetamido)-2,4,6-triiodobenzoyloxy)malonate；Diethyl 2-(3,5-diacetamido-2,4,6-triiodobenzoyl)oxypropanedioate
• CAS: 153339-44-7
• 化学式: C₁₈H₁₉I₃N₂O₈
• 分子量: 772.071
• InChiKey: BCTYMMBHNTWEKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  137
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Composition of and method for preparing stable particles in a frozen aqueous matrix
  申请人：——

  公开号：US20030077329A1

  公开（公告）日：2003-04-24

  The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The composition is stable for a prolonged period of time, preferably six months or longer and is suitable for parenteral, oral, or non-oral routes such as pulmonary (inhalation), ophthalmic, or topical administration.

  本发明揭示了一种稳定的悬浮液组合物，其包含一种难溶于水的药物或化妆品，以药物或化妆品的颗粒形式悬浮于冻结水基体中，并揭示了其制备方法。该组合物稳定性长时间，优选为六个月或更长时间，适用于静脉、口服或非口服途径，例如肺部（吸入）、眼科或局部给药。
• COMPOSITION OF AND METHOD FOR PREPARING STABLE PARTICLES IN A FROZEN AQUEOUS MATRIX
  申请人：Kipp E. James

  公开号：US20060222710A1

  公开（公告）日：2006-10-05

  The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The composition is stable for a prolonged period of time, preferably six months or longer and is suitable for parenteral, oral, or non-oral routes such as pulmonary (inhalation), ophthalmic, or topical administration.

  本发明揭示了一种稳定的悬浮液组合物，该组合物以制药剂或化妆品的颗粒形式悬浮于冻结的水基基质中，并提供了其制备方法。该组合物稳定性能长时间保持，最好为六个月或更长时间，并适用于肠道内、口服或非口服途径，如肺部（吸入）、眼科或局部给药。
• (Polyalkoxy)sulfonate surface modifiers
  申请人：Kipp E. James

  公开号：US20060141048A1

  公开（公告）日：2006-06-29

  The present invention is directed to novel compounds, methods of manufacture and methods of use. The present invention is also directed to solid drug/active agent particles having one or more of the compounds of the present invention associated with the surface thereof. The compounds of the present invention are comprised of a non-polar polyether covalently linked to an anionic sulfonate group. The compounds have an amphipathic quality and preferably, are surface active. Such compounds are preferably useful as surface-active agents to coat and stabilize dispersions of particles in a continuous liquid medium. These surface-active agents may be applied in the stabilization of suspensions, emulsions, or liposome formulations intended for pharmaceutical, medical, cosmetic, or agricultural use. The particles that can be prepared by a variety of methods and will preferably comprise a pharmaceutical agent. Pharmaceutical compositions of the present invention can be used to treat a myriad of conditions and can be administered by many routes, including intravenous, intramuscular, subcutaneous, intrathecal, subdural, intracameral, intracerebral, intralesional, topical, oral, buccal, rectal, transcutaneous, pulmonary, and nasal.

  本发明涉及新型化合物、制造方法和使用方法。本发明还涉及具有本发明化合物中的一个或多个与其表面相关联的固体药物/活性剂颗粒。本发明化合物由非极性聚醚共价连接到阴离子磺酸基团上。该化合物具有两性性质，最好是表面活性。这样的化合物最好用作表面活性剂，用于包覆和稳定分散在连续液体介质中的颗粒。这些表面活性剂可用于稳定制药、医疗、化妆品或农业用途的悬浮液、乳液或脂质体制剂。可通过各种方法制备颗粒，颗粒最好包含一种药物。本发明的制药组合物可用于治疗多种疾病，并可通过许多途径给药，包括静脉、肌肉注射、皮下注射、蛛网膜下腔、硬膜外、眼前房、颅内、病变部位内、局部、口服、颊粘膜、直肠、经皮、肺和鼻腔。
• Iodinated aromatic propanedioates and their use as X-ray contrast agents
  申请人：NanoSystems L.L.C.

  公开号：EP0618189A1

  公开（公告）日：1994-10-05

  Compounds having the structure    wherein (Z)̵COO is the residue of an iodinated aromatic acid;    R¹ and R² are independently alkyl, fluoroalkyl, cycloalkyl, aryl or aralkyl; and    R³ is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, cyano, sulfonate, carboxamido, sulfonamido, CO₂-alkyl, CO₂-aryl or CO₂-aralkyl;    are useful as contrast agents in x-ray imaging compositions and methods for diagnostic imaging.

  具有以下结构的化合物 其中 (Z)̵COO 是碘化芳香酸的残留物； R¹ 和 R² 独立地是烷基、氟烷基、环烷基、芳基或芳烷基；以及 R³ 是 H、烷基、氟烷基、环烷基、芳基、芳烷基、烷氧基、芳氧基、氰基、磺酸基、羧酰胺基、磺酰胺基、CO₂-烷基、CO₂-芳基或 CO₂-芳烷基； 可用作 X 射线成像组合物和诊断成像方法中的造影剂。
• Compositions and methods using same for delivering agents into a target organ protected by a blood barrier
  申请人：Biorest Ltd.

  公开号：EP2279726A2

  公开（公告）日：2011-02-02

  A liposome for use in delivering a pharmaceutical agent into a target organ protected by a blood barrier comprises a pharmaceutical agent targeted at an organ protected by said blood brain barrier, wherein said liposome is accumulated in a cell of an immune system of said subject to thereby generate a liposome loaded immune cell, said liposome loaded immune cell is capable of crossing the blood barrier, where an amount of the pharmaceutical agent is released from said liposome in the target organ of the subject.

  一种用于向受血脑屏障保护的靶器官输送药剂的脂质体，包括针对受血脑屏障保护的器官的药剂，其中所述脂质体在所述受试者的免疫系统细胞中积聚，从而生成脂质体负载免疫细胞，所述脂质体负载免疫细胞能够穿过血脑屏障，其中一定量的药剂从所述脂质体中释放到受试者的靶器官中。