N-(3-methoxypropyl)-N-[[2-[4-(morpholin-4-ylmethyl)phenyl]phenyl]methyl]-2-phenylacetamide | 1100255-72-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-methoxypropyl)-N-[[2-[4-(morpholin-4-ylmethyl)phenyl]phenyl]methyl]-2-phenylacetamide
• CAS: 1100255-72-8
• 化学式: C₃₀H₃₆N₂O₃
• 分子量: 472.627
• InChiKey: PPOMBOJOMLCKKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  42
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吗啉 、 N-((4'-formyl-[1,1'-biphenyl]-2-yl)methyl)-N-(3-methoxypropyl)-2-phenylacetamide 在 三乙酰氧基硼氢化钠 作用下， 以 二氯甲烷 为溶剂， 生成 N-(3-methoxypropyl)-N-[[2-[4-(morpholin-4-ylmethyl)phenyl]phenyl]methyl]-2-phenylacetamide
  参考文献：
  名称：

  Identification of small molecule agonists of the motilin receptor

  摘要：

  High-throughput screening resulted in the identification of a series of novel motilin receptor agonists with relatively low molecular weights. The series originated from an array of biphenyl derivatives designed to target 7-transmembrane (7-TM) receptors. Further investigation of the structure-activity relationship within the series resulted in the identi. cation of compound (22) as a potent and selective agonist at the motilin receptor. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.071

文献信息

• Identification of small molecule agonists of the motilin receptor
  作者：Tom D. Heightman、Elizabeth Conway、David F. Corbett、Gregor J. Macdonald、Geoffrey Stemp、Susan M. Westaway、Paolo Celestini、Stefania Gagliardi、Mauro Riccaboni、Silvano Ronzoni、Kalindi Vaidya、Sharon Butler、Fiona McKay、Alison Muir、Ben Powney、Kim Winborn、Alan Wise、Emma M. Jarvie、Gareth J. Sanger

  DOI：10.1016/j.bmcl.2008.10.071

  日期：2008.12

  High-throughput screening resulted in the identification of a series of novel motilin receptor agonists with relatively low molecular weights. The series originated from an array of biphenyl derivatives designed to target 7-transmembrane (7-TM) receptors. Further investigation of the structure-activity relationship within the series resulted in the identi. cation of compound (22) as a potent and selective agonist at the motilin receptor. (C) 2008 Elsevier Ltd. All rights reserved.