6-methyl-6-[3-(1-methylindol-3-yl)-1,2,4-oxadiazol-5-yl]-N-[4-(trifluoromethyl)phenyl]-2-azabicyclo[2.2.2]octane-2-carboxamide | 1186580-97-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-methyl-6-[3-(1-methylindol-3-yl)-1,2,4-oxadiazol-5-yl]-N-[4-(trifluoromethyl)phenyl]-2-azabicyclo[2.2.2]octane-2-carboxamide
• CAS: 1186580-97-1
• 化学式: C₂₇H₂₆F₃N₅O₂
• 分子量: 509.531
• InChiKey: JCJGPIPXKGAQSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  37
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  76.2
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• SOLUBLE EPOXIDE HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：Shen Hong

  公开号：US20110003849A1

  公开（公告）日：2011-01-06

  Compounds of the formula: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating diabetes, inflammation, atherosclerosis, hypertension, pain and the like are disclosed. Pharmaceutical compositions and methods of use are also included.