2-(N-(3,5-dichlorophenyl)-2-hydroxybenzamido)acetic acid | 1064652-75-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(N-(3,5-dichlorophenyl)-2-hydroxybenzamido)acetic acid
• 英文别名: 2-(3,5-dichloro-N-(2-hydroxybenzoyl)anilino)acetic acid
• CAS: 1064652-75-0
• 化学式: C₁₅H₁₁Cl₂NO₄
• 分子量: 340.163
• InChiKey: DACIPZZDIBGJCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  tert-butyl 2-(N-(3,5-dichlorophenyl)-2-hydroxybenzamido)acetate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以50 mg的产率得到2-(N-(3,5-dichlorophenyl)-2-hydroxybenzamido)acetic acid
  参考文献：
  名称：

  Salicylanilides: Selective inhibitors of interleukin-12p40 production

  摘要：

  Interleukin (IL)-12p40, a subunit component of both IL-12 and IL-23, is being widely studied for its role in in. ammatory disease. As part of an effort to pro. le cellular signaling pathways across different cell types, we report salicylanilide inhibitors of IL-12p40 production in stimulated dendritic cells. Based on a hypothesis that a desirable therapeutic pro. le is one that could block IL-12p40 but not IL-6 production, we engaged in directed analoging. This resulted in salicylanilides with similar IL-12p40 related potency but enhanced selectivity relative to IL-6 production. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2008.07.024

文献信息

• Salicylanilides: Selective inhibitors of interleukin-12p40 production
  作者：Michael E. Brown、Jeffrey N. Fitzner、Tracey Stevens、Wilson Chin、Clifford D. Wright、Jim P. Boyce

  DOI：10.1016/j.bmc.2008.07.024

  日期：2008.9

  Interleukin (IL)-12p40, a subunit component of both IL-12 and IL-23, is being widely studied for its role in in. ammatory disease. As part of an effort to pro. le cellular signaling pathways across different cell types, we report salicylanilide inhibitors of IL-12p40 production in stimulated dendritic cells. Based on a hypothesis that a desirable therapeutic pro. le is one that could block IL-12p40 but not IL-6 production, we engaged in directed analoging. This resulted in salicylanilides with similar IL-12p40 related potency but enhanced selectivity relative to IL-6 production. (C) 2008 Published by Elsevier Ltd.