2-Bromo-5-propylpyridine | 1159821-61-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Bromo-5-propylpyridine
• CAS: 1159821-61-0
• 化学式: C₈H₁₀BrN
• 分子量: 200.08
• InChiKey: MHLLUSHSDFVJLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] ANTIMALARIAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIPALUDIQUES
  申请人：LIVERPOOL SCHOOL TROPICAL MEDICINE

  公开号：WO2012069856A1

  公开（公告）日：2012-05-31

  The present invention relates to antimalarial compounds. More specifically, the present invention relates to novel substituted quinolone derivatives of formula (I) and related quinoline derivatives of formula (II) as defined herein that possess potent antimalarial activity. The present invention also relates to processes for the preparation of these quinolone and quinoline derivatives, to pharmaceutical compositions comprising them and to their use as therapeutic agents for the treatment and/or prevention of malaria.

  本发明涉及抗疟疾化合物。更具体地，本发明涉及具有强效抗疟活性的本发明中定义的新型取代喹诺酮衍生物（式（I））和相关喹啉衍生物（式（II））。本发明还涉及制备这些喹诺酮和喹啉衍生物的方法，包括含有它们的药物组合物以及它们作为治疗和/或预防疟疾的治疗剂的用途。
• [EN] SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS<br/>[FR] COMPOSÉS N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDES SUBSTITUÉS EN TANT QU'INHIBITEURS DE TYROSINE KINASE DE RÉCEPTEURS DE TYPE III
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2012082689A1

  公开（公告）日：2012-06-21

  Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

  公式I的化合物及其药学上可接受的盐，在其中R1、R2、R3、R4、R5和R6具有规范中给定的含义，是cFMS的抑制剂，并且在治疗哺乳动物的纤维化、与骨相关的疾病、癌症、自身免疫性疾病、炎症性疾病、心血管疾病、疼痛和烧伤方面是有用的。
• [EN] HETEROCYCLIC COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES UTILISÉS EN TANT QU'ANTAGONISTES DES RÉCEPTEURS CCR1
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2011056440A1

  公开（公告）日：2011-05-12

  Disclosed are CCR1 receptor antagonists of the formula (I) wherein Ar1, Ar2, R1-R3, X and L are disclosed herein. Also disclosed are compositions, methods of making and using compounds of the formula (I).

  揭示了公式（I）中的CCR1受体拮抗剂，其中Ar1、Ar2、R1-R3、X和L在此处披露。还披露了公式（I）化合物的组成、制备方法和使用方法。
• NEPRILYSIN INHIBITORS
  申请人：Fleury Melissa

  公开号：US20120309724A1

  公开（公告）日：2012-12-06

  In one aspect, the invention relates to compounds having the formula: where R 1 , R 2 , R 3 , X, R 4 , R 5 , and R 6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

  在一个方面，该发明涉及具有以下公式的化合物：其中R1、R2、R3、X、R4、R5和R6如规范中所定义，或其药用可接受盐。这些化合物具有神经肽酶抑制活性。在另一个方面，该发明涉及包含这些化合物的药物组合物；使用这些化合物的方法；以及制备这些化合物的过程和中间体。
• [EN] INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES<br/>[FR] INHIBITEURS DE LA RÉPLICATION VIRALE, LEUR PROCÉDÉ DE PRÉPARATION ET LEURS UTILISATIONS THÉRAPEUTIQUES
  申请人：BIODIM LAB

  公开号：WO2014053666A1

  公开（公告）日：2014-04-10

  The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

  本发明涉及化合物，其在治疗或预防病毒性疾病，包括艾滋病方面的应用。