N-Methyl-azepin | 14229-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 金属杂环化合物
• 英文名称: N-Methyl-azepin
• 英文别名: N-methylazepine；1-methylazepine
• CAS: 14229-43-7
• 化学式: C₇H₉N
• 分子量: 107.155
• InChiKey: ILKWEPWYWBCGSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Novel Dosage Form
  申请人：NeuroVive Pharmaceutical AB

  公开号：US20140234414A1

  公开（公告）日：2014-08-21

  There is provided inter alia a pharmaceutical dosage form for oral administration comprising a sanglifehrin as active ingredient in which the sanglifehrin active ingredient is protected from acid degradation in the stomach environment following oral administration.

  提供了一种用于口服的药物剂型，包括桑格利非林作为活性成分，其中桑格利非林活性成分在口服后受到胃酸降解的保护。
• [EN] NUCLEOTIDE ANALOGUE, METHOD OF SYNTHESIS OF NUCLEOTIDE ANALOGUE, USE OF NUCLEOTIDE ANALOGUE, ANTIVIRAL PRO-NUCLEOTIDE, PHARMACEUTICAL COMPOSITION<br/>[FR] ANALOGUE NUCLÉOTIDIQUE, LEUR PROCÉDÉ DE SYNTHÈSE ET UTILISATION, PRO-NUCLÉOTIDE ANTIVIRAL, COMPOSITION PHARMACEUTIQUE
  申请人：INST CHEMII BIOORG PAN

  公开号：WO2012053917A1

  公开（公告）日：2012-04-26

  The object of the invention are nucleotide analogues, antiviral pro-nucleotides, a use of nucleotide analogues and pharmaceutical composition, a phosphorylating agent for synthesis of nucleotide analogue, and a method of synthesis of nucleotide analogue. More precisely, the invention applies to the new group of nucleotide analogues and their use in partial or complete inhibition of human immunodeficiency virus (HIV).

  本发明的对象是核苷酸类似物、抗病毒前核苷酸、核苷酸类似物的使用和制药组合物、用于合成核苷酸类似物的磷酸化剂以及核苷酸类似物的合成方法。更具体地，本发明适用于新的核苷酸类似物群体及其在部分或完全抑制人类免疫缺陷病毒（HIV）中的应用。
• Novel cytostatic conjugates with integrin ligands
  申请人：Lerchen Hans-Georg

  公开号：US20080108576A1

  公开（公告）日：2008-05-08

  The present invention relates to cytostatics which have a tumour-specific action as a result of linkage to α v β 3 integrin antagonists via preferred linking units which can be selectively cleaved by elastase, i.e. by an enzyme which can especially be found in tumour tissue. The preferred linking units provide sufficient stability of the conjugate of cytostatic and α v β 3 integrin antagonist in biological fluids and, at the same time, the desired intracellular action within tumour cells as a result of its specific enzymatic or hydrolytic cleavability with release of the cytostatic.

  本发明涉及一种细胞毒素，通过与αvβ3整合素拮抗剂通过优选的连接单元结合，从而具有肿瘤特异性作用，这些连接单元可以被弹性蛋白酶选择性地剪断，即一种特别存在于肿瘤组织中的酶。优选的连接单元在生物液体中为细胞毒素和αvβ3整合素拮抗剂的结合物提供足够的稳定性，并且通过特定的酶解或水解释放细胞毒素，在肿瘤细胞内实现所需的细胞内作用。
• Macrocyclic Compounds and Methods for Their Production
  申请人：Moss Steven James

  公开号：US20140038885A1

  公开（公告）日：2014-02-06

  There is provided inter alia compounds of formula (I): for use in treatment of viral infection or as an immunosuppressant.

  提供了公式（I）的化合物，可用于治疗病毒感染或作为免疫抑制剂。
• ANTHELMINTIC QUATERNARYALKYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS
  申请人：THE UPJOHN COMPANY

  公开号：EP0299972B1

  公开（公告）日：1992-03-04