N-phenyl-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide | 1132666-82-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide
• 英文别名: N-phenyl-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide
• CAS: 1132666-82-0
• 化学式: C₂₃H₁₉N₅O
• 分子量: 381.4
• InChiKey: NJPAKBYFJXINIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  79.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Combination Therapy
  申请人：Li Zuomei

  公开号：US20090124631A1

  公开（公告）日：2009-05-14

  The invention relates to the treatment of mammalian diseases manifested by abnormal cell growth and/or abnormal cell proliferation. More particularly, the invention relates to the use of combination therapies to control abnormal cell growth and/or abnormal cell proliferation. In particular, the invention relates to the use of isotype-selective inhibitors of histone deacetylases 1, 2 and/or 3 (HDACs 1-3), as well as isotype-selective inhibitors of HDAC1 and/or HDAC2, to potentiate therapeutic activity of microtubule-stabilization agents.