1-pentyl-imidazolidin-2-one | 40424-29-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-pentyl-imidazolidin-2-one
• 英文别名: 1-Pentylimidazolidin-2-one
• CAS: 40424-29-1
• 化学式: C₈H₁₆N₂O
• 分子量: 156.228
• InChiKey: LYFADTFKQMNOQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS<br/>[FR] HYDANTOÏNE CONTENANT DES INHIBITEURS DE LA DÉSOXYURIDINE TRIPHOSPHATASE
  申请人：CV6 THERAPEUTICS NI LTD

  公开号：WO2018098206A1

  公开（公告）日：2018-05-31

  Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

  提供的是dUTPase抑制剂，包含此类化合物的组合物以及使用此类化合物和组合物的方法。
• [DE] NEUE, ANTIKONVULSIV WIRKENDE 1-AR(ALK)YL-IMIDAZOLIN-2-ONE, DIE IN 4-STELLUNG EINEN DISUBSTITUIERTEN AMIN-REST ENTHALTEN, UND VERFAHREN ZU DEREN HERSTELLUNG<br/>[EN] NOVEL 1-AR(ALK)YL-IMIDAZOLIN-2-ONES CONTAINING A DISUBSTITUTED AMINE RADICAL IN THE 4TH POSITION, HAVING AN ANTI-CONVULSIVE EFFECT, AND PROCESS FOR THEIR PRODUCTION<br/>[FR] NOUVELLES 1-AR(ALK)YL-IMIDAZOLIN-2-ONES A EFFET ANTICONVULSIF CONTENANT UN RESTE AMINE BISUBSTITUE EN POSITION 4 ET PROCEDE PERMETTANT DE LES PREPARER
  申请人：ARZNEIMITTELWERK DRESDEN GMBH

  公开号：WO1997009314A1

  公开（公告）日：1997-03-13

  (DE) Antikonvulsiv wirkende Verbindungen der allgemeinen Formel (1), worin X = Wasserstoff, C1-C4-Alkyl, C1-C4-Alkoxy, Trifluormethyl, Halogen, R1 bzw. R2 = C1-C4-Alkyl, Cycloalkyl, Heteroalkyl bedeuten.(EN) Compounds with an anti-convulsive effect of general formula (1) in which X = hydrogen, C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl, halogen and R1 or R2 = C1-C4 alkyl, cycloalkyl or heteroalkyl.(FR) L'invention concerne des composés à effet anticonvulsif de la formule générale (1) dans laquelle X désigne hydrogène, alkyle C1-C4, alcoxy C1-C4, trifluorométhyle, halogène, R1 et respectivement R2 désignent alkyle C1-C4, cycloalkyle, hétéroalkyle.

  (中文) 通式（1）的抗癫痫化合物，其中X = 氢，C1-C4烷基，C1-C4烷氧基，三氟甲基，卤素，R1或R2 = C1-C4烷基，环烷基或杂环烷基。
• N-alkanoylphenylalanine derivatives
  申请人：——

  公开号：US20040210051A1

  公开（公告）日：2004-10-21

  Compounds of the formula: 1 are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

  公式为1的化合物被披露，其具有作为VCAM-1和表达VLA-4的细胞之间结合抑制剂的活性。这些化合物对于治疗其症状和/或损伤与VCAM-1与表达VLA-4的细胞之间的结合有关的疾病是有用的。
• Diephenyl carbocyclic thioamide derivatives
  申请人：——

  公开号：US20010041799A1

  公开（公告）日：2001-11-15

  It has been discovered that compounds of the formula: 1 and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (I BD).

  已发现以下化合物的公式：1及其药学上可接受的盐和酯，其中X和Y的定义如下，能够抑制VCAM-1与VLA-4的结合，并且适用于治疗与慢性炎症性疾病相关的炎症，例如类风湿性关节炎（RA），多发性硬化症（MS），哮喘和炎症性肠病（I BD）。
• PHENYL-KETO-IMIDAZOLIDINE THIOAMIDE DERIVATIVES
  申请人：——

  公开号：US20020010338A1

  公开（公告）日：2002-01-24

  It has been discovered that compounds of the formula: 1 and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (I BD).

  已经发现了以下化合物的公式1及其药学上可接受的盐和酯，其中X和Y的定义如下，可以抑制VCAM-1与VLA-4的结合，并且在治疗与慢性炎症性疾病相关的炎症方面非常有用，如类风湿性关节炎（RA），多发性硬化症（MS），哮喘和炎症性肠病（IBD）。