2-(2-Methyl-5-Nitro-1H-Indol-3-Ylmethylene)-Malononitrile | 691887-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(2-Methyl-5-Nitro-1H-Indol-3-Ylmethylene)-Malononitrile
• 英文别名: 2-[(2-methyl-5-nitro-1H-indol-3-yl)methylidene]propanedinitrile
• CAS: 691887-28-2
• 化学式: C₁₃H₈N₄O₂
• 分子量: 252.232
• InChiKey: INFXWLRUUPQESN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  7-硝基-1H-吲哚-2-甲酸乙酯 、 2-羟基丁二腈 在 哌啶 作用下， 以 乙醇 为溶剂， 生成 2-(2-Methyl-5-Nitro-1H-Indol-3-Ylmethylene)-Malononitrile
  参考文献：
  名称：

  Chemical uncouplers for the treatment of obesity

  摘要：

  这项发明涉及一种化学解偶联剂，它具有更宽的安全窗口，使其在治疗肥胖症以及因此引发的相关疾病和状况，如动脉硬化、高血压、糖尿病（尤其是2型糖尿病（非胰岛素依赖型糖尿病））、葡萄糖耐量受损、血脂异常、冠心病、胆结石病、骨关节炎以及子宫内膜、乳房、前列腺和结肠等各种癌症以及过早死亡的风险等方面更具吸引力。此外，还包括其他通过增加线粒体呼吸得到改善的条件、疾病和紊乱。

  公开号：

  US20040138301A1

文献信息

• Methods and compositions for treating obesity, preventing weight gain, promoting weight loss, promoting slimming, or treating or preventing the development of diabetes
  申请人：NAN Global, LLC

  公开号：US10849872B2

  公开（公告）日：2020-12-01

  The present invention relates to compositions and kits including a chemical uncoupler, such as tyrphostin 9 or precursor or a salt thereof, and compositions including a chemical uncoupler, such as tyrphostin 9 in combination with one or more therapeutic agents, for example, L-carnitine, which are useful, for example, in treating obesity, preventing weight gain, promoting weight loss/slimming, and/or treating or preventing the development of diabetes.

  本发明涉及包括化学解偶联剂的组合物和试剂盒，如tyrphostin 9或其前体或盐，以及包括化学解偶联剂的组合物，如tyrphostin 9与一种或多种治疗剂（例如左旋肉碱）的组合物，这些组合物在治疗肥胖症、防止体重增加、促进减肥/瘦身和/或治疗或预防糖尿病发展等方面有用。
• SAFE CHEMICAL UNCOUPLERS FOR THE TREATMENT OF OBESITY
  申请人：NOVO NORDISK A/S

  公开号：EP1575575A2

  公开（公告）日：2005-09-21
• METHODS AND COMPOSITIONS FOR TREATING OBESITY, PREVENTING WEIGHT GAIN, PROMOTING WEIGHT LOSS, PROMOTING SLIMMING, OR TREATING OR PREVENTING THE DEVELOPMENT OF DIABETES
  申请人：NAN Global, LLC

  公开号：US20160000745A1

  公开（公告）日：2016-01-07

  The present invention relates to compositions and kits including a chemical uncoupler, such as tyrphostin 9 or precursor or a salt thereof, and compositions including a chemical uncoupler, such as tyrphostin 9 in combination with one or more therapeutic agents, for example, L-carnitine, which are useful, for example, in treating obesity, preventing weight gain, promoting weight loss/slimming, and/or treating or preventing the development of diabetes.
• [EN] SAFE CHEMICAL UNCOUPLERS FOR THE TREATMENT OF OBESITY<br/>[FR] DECOUPLEURS CHIMIQUES SURS POUR LE TRAITEMENT DE L'OBESITE
  申请人：NOVO NORDISK AS

  公开号：WO2004041256A2

  公开（公告）日：2004-05-21

  This invention relates to chemical uncouplers with a broader safety window making the use of them in treating obesity and, consequently, in the treatment of obesity related dis-eases and conditions such as atherosclerosis, hypertension, diabetes, especially type 2 dia-betes (NIDDM (non-insulin dependent diabetes mellitus)), impaired glucose tolerance, dyslip-idemia, coronary heart disease, gallbladder disease, osteoarthritis and various types of can-cer such as endometrial, breast, prostate and colon cancers and the risk for premature death as well as other conditions, such as diseases and disorders, which conditions are improved by an increase in mitochondrial respiration, more attractive.