ethyl (2E,4Z)-5-[2-[(1S)-1-(cyclohexanecarbonylamino)-2-(4-phenylmethoxyphenyl)ethyl]-1,3-thiazol-4-yl]-2,4-dimethylpenta-2,4-dienoate | 1056750-86-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl (2E,4Z)-5-[2-[(1S)-1-(cyclohexanecarbonylamino)-2-(4-phenylmethoxyphenyl)ethyl]-1,3-thiazol-4-yl]-2,4-dimethylpenta-2,4-dienoate
• CAS: 1056750-86-7
• 化学式: C₃₄H₄₀N₂O₄S
• 分子量: 572.769
• InChiKey: VQFDMIMZQWVEGS-FNGWRSIMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  41
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Protein Tyrosine Phosphatase 1B Inhibitor, Preparation Methods and Uses Thereof
  申请人：Nan Fajun

  公开号：US20100197927A1

  公开（公告）日：2010-08-05

  PTP1B inhibitors with the following structure (formula I). Experiments indicate that these inhibitors can effectively inhibit the activity of protein tyrosine phosphatase 1B (PTP1B). They can be used as insulin sensitisers. They can be used to prevent, delay or treat diseases which are related to insulin antagonism mediated by PTP1B, especially diabetes type II and obesity. The invention also provides methods for preparing these inhibitors.
• US8183383B2
  申请人：——

  公开号：US8183383B2

  公开（公告）日：2012-05-22