2-Amino-3'-hydroxy-diphenylaether | 93001-68-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Amino-3'-hydroxy-diphenylaether
• 英文别名: 3-(2-amino-phenoxy)-phenol；3-(2-Aminophenoxy)phenol
• CAS: 93001-68-4
• 化学式: C₁₂H₁₁NO₂
• 分子量: 201.225
• InChiKey: AMJDJQMVOKXENA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Amino-3'-hydroxy-diphenylaether 生成 2,2'-Azo-5-hydroxy-diphenylaether = 2-Hydroxy-dibenzo<1,4,5>oxadiazepin
  参考文献：
  名称：

  Aromatic and Pseudoaromatic Non-benzenoid Systems. III. The Synthesis of Some Ten π-Electron Systems^1-3

  摘要：

  DOI：

  10.1021/ja00865a030
• 作为产物：
  描述：

  1-(3-甲氧基苯氧基)-2-硝基苯 在 氢碘酸 作用下， 生成 2-Amino-3'-hydroxy-diphenylaether
  参考文献：
  名称：

  Aromatic and Pseudoaromatic Non-benzenoid Systems. III. The Synthesis of Some Ten π-Electron Systems^1-3

  摘要：

  DOI：

  10.1021/ja00865a030

文献信息

• PCNA inhibitors
  申请人：City of Hope

  公开号：US11345656B2

  公开（公告）日：2022-05-31

  Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.

  本文特别描述了 PCNA 调节剂的组合物以及治疗或预防癌症的方法。
• IDO INHIBITORS AND THERAPEUTIC USES THEREOF
  申请人：Roehrig Ute

  公开号：US20110112282A1

  公开（公告）日：2011-05-12

  Compounds of formula (I), and pharmaceutically acceptable salts thereof, in which each compound is adapted to occupy the binding site of human IDO, which comprises a large hydrophobic pocket A and a second, proximal hydrophobic pocket B, the compound comprising at least one of the following elements: (i) a large hydrophobic fragment to substantially fill pocket A in the binding site of human IDO; (ii) an atom that can coordinate to the heme iron of human IDO, (iii) a positively charged group that can form a salt-bridge with the heme 7-propionate of the human IDO; (iv) a negatively charged group that can form a salt-bridge with Arg231 of the human IDO; (v) a hydrophobic group that can form van der Waals interactions with pocket B; and (vi) one or more substituents that can hydrogen bond to Ser167 and to Gly262, and as IDO inhibitors and their therapeutic use, eg in the treatment of cancer.
• PCNA INHIBITORS
  申请人：City of Hope

  公开号：US20210078938A1

  公开（公告）日：2021-03-18

  Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.
• <b>Aromatic and Pseudoaromatic Non-benzenoid Systems. III. The Synthesis of Some Ten π-Electron Systems^1-3</b>
  作者：Norman L. Allinger、Gilbert A. Youngdale

  DOI：10.1021/ja00865a030

  日期：1962.3