盐酸哌苯甲醇 | 71-78-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 盐酸哌苯甲醇
• 中文别名: N,N"-二乙酰基乙二胺
• 英文名称: pipradrol hydrochloride
• 英文别名: 2-(Diphenylhydroxymethyl)-piperidin-hydrochlorid；diphenyl(piperidin-2-yl)methanol;hydron;chloride
• CAS: 71-78-3
• 化学式: C₁₈H₂₁NO*ClH
• 分子量: 303.832
• InChiKey: KIFIYUHFHGSNHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.49
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  32.3
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• Hybridoma cell line of secreting meloxicam monoclonal antibodies and application thereof
  申请人：JIANGNAN UNIVERSITY

  公开号：US10562979B1

  公开（公告）日：2020-02-18

  A hybridoma cell line of secreting meloxicam monoclonal antibodies with a preservation number of hybridoma cell line of CGMCC No. 14700 belongs to the field of food safety immunological detection. The. BALB/c mice are immunized through one time immunization with complete freund's adjuvant, three times of booster immunization with incomplete freund's adjuvant and one time of rush immunization with meroxicam complete antigen without adjuvant; the spleen cells from BALB/C mice immunized with high potency and low value of IC50 are fused with murine myeloma cells; and then the hybridoma cell line is obtained through indirect competitive ELISA screening and three sub-clones. The monoclonal antibody secreted by this cell line has good specificity and detection sensitivity to meloxicam (value of IC50 is 0.1 ng/ml), being suitable for detection of meroxicam in food.

  一种分泌美洛昔康单克隆抗体的杂交瘤细胞系，其杂交瘤细胞系保藏号为CGMCC第14700号，属于食品安全免疫检测领域。实验方法用完全弗氏佐剂免疫BALB/c小鼠1次，不完全弗氏佐剂加强免疫3次，美洛昔康完全抗原不加佐剂急速免疫1次，将免疫效价高、IC50值低的BALB/C小鼠脾脏细胞与小鼠骨髓瘤细胞融合，通过间接竞争性ELISA筛选得到杂交瘤细胞系，并得到3个亚克隆。该细胞系分泌的单克隆抗体对美洛昔康具有良好的特异性和检测灵敏度（IC50 值为 0.1 ng/ml），适用于食品中美洛昔康的检测。
• Pharmaceutical dosage form for pulsatile delivery of methylphenidate
  申请人：——

  公开号：US20020058061A1

  公开（公告）日：2002-05-16

  Novel pharmaceutical dosage forms provide for pulsatile delivery of methylphenidate, i.e., release encapsulated drug in spaced apart “pulses.” The dosage forms are comprised of first, second and optionally third dosage units, with each dosage unit having a different drug release profile. The dosage forms may comprise capsules housing compressed tablets or drug-containing beads or particles, or may comprise a single tablet with the first, second and optionally third dosage units each representing an integral and discrete segment thereof. Methods of treatment using the pharmaceutical dosage forms are provided as well.

  新型药物剂型可脉冲式释放哌醋甲酯，即以间隔的 "脉冲 "方式释放封装药物。这些剂型由第一、第二和可选的第三剂量单位组成，每个剂量单位具有不同的药物释放曲线。这些剂型可包括容纳压缩片剂或含药微珠或微粒的胶囊，也可包括第一、第二和第三剂量单位各自代表其整体和离散部分的单一片剂。此外，还提供了使用药物剂型的治疗方法。
• Medicated plasters
  申请人：NITTO DENKO CORPORATION

  公开号：EP0387751B1

  公开（公告）日：1994-06-08
• PHARMACEUTICAL DOSAGE FORM FOR PULSATILE DELIVERY OF METHYLPHENIDATE
  申请人：Pharmaquest Limited

  公开号：EP1165054A1

  公开（公告）日：2002-01-02
• EP1165054A4
  申请人：——

  公开号：EP1165054A4

  公开（公告）日：2005-02-09