2,4-Dihydroxy-3-{3-[(2S,4aS,8S)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonaphthalen-8-yl]propanamido}benzoic acid | 869898-86-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-Dihydroxy-3-{3-[(2S,4aS,8S)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonaphthalen-8-yl]propanamido}benzoic acid
• 英文别名: 2,4-dihydroxy-3-[3-[(1S,5S,8S)-5-methyl-9-methylidene-4-oxo-5-tricyclo[6.2.2.01,6]dodec-2-enyl]propanoylamino]benzoic acid
• CAS: 869898-86-2
• 化学式: C₂₄H₂₇NO₆
• 分子量: 425.5
• InChiKey: DWUHGPPFFABTIY-KMVHLTCXSA-N

物化性质

• 沸点：
  670.1±55.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)
• 溶解度：
  DMF：可溶； DMSO：可溶；乙醇：可溶；甲醇：可溶

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• METHOD OF TREATMENT USING FATTY ACID SYNTHESIS INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2946778A1

  公开（公告）日：2015-11-25

  The present invention relates to natural products that possess fatty acid synthesis inhibitor activity and can be used to treat or prevent dyslipidemias.

  本发明涉及具有脂肪酸合成抑制剂活性并可用于治疗或预防血脂异常的天然产品。
• Method of treatment using fatty acid synthesis inhibitors
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2698157B1

  公开（公告）日：2015-05-20
• PLATENSIMYCIN BIOSYNTHETIC GENE CLUSTER OF STREPTOMYCES PLATENSIS
  申请人：SHEN BEN

  公开号：US20090081673A1

  公开（公告）日：2009-03-26

  The present invention relates to the cloning and sequence of a biosynthetic gene cluster from Streptomyces platensis that produces platensimycin and platencin. Also provided are engineered micro-organisms for the production of these compounds, and analogs thereto, as well as methods of screening for compounds with anti-bacterial activity.
• Antibiotic Compound
  申请人：Basilio Angela

  公开号：US20100144879A1

  公开（公告）日：2010-06-10

  Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structural formula (I).
• US7807445B2
  申请人：——

  公开号：US7807445B2

  公开（公告）日：2010-10-05