3-甲基-2-苯基噻唑烷 | 7739-01-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-甲基-2-苯基噻唑烷
• 英文名称: 2-phenyl-3-methylthiazolidine-1,3
• 英文别名: 3-methyl-2-phenyl-thiazolidine；3-Methyl-2-phenyl-thiazolidin；Methyl-3-phenyl-thiazolidin；3-Methyl-2-phenylthiazolidine；3-methyl-2-phenyl-1,3-thiazolidine
• CAS: 7739-01-7
• 化学式: C₁₀H₁₃NS
• 分子量: 179.286
• InChiKey: MZXDFRDYHHUXNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-甲基-2-苯基噻唑烷 、 碘甲烷 生成 3,3-Dimethyl-2-phenyl-1,3-thiazolidin-3-ium iodide
  参考文献：
  名称：

  WITEK, S.;BIELAWSKA, A.;BIELAWSKI, J., POL. J. CHEM., 1982, 56, N 1, 207-212

  摘要：

  DOI：
• 作为产物：
  描述：

  3-methyl-2-phenyl-Δ²-thiazolinium iodide 在 sodium cyanoborohydride 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以25%的产率得到3-甲基-2-苯基噻唑烷
  参考文献：
  名称：

  氰基硼氢化钠的反应，与苯并噻唑鎓和Δ 2 -thiazolinium阳离子。苯并噻唑啉，噻唑烷和稳定的噻唑硼烷的形成

  摘要：

  苯并噻唑的氰基硼氢化钠还原和Δ 2层-thiazolinium的阳离子，能benzothiazolines和噻唑烷地连同[[ - （二取代的氨基）苯基]和2-（二烷基氨基）乙基]硫代] boranecarbonitriles（- ）和。由于通过N→B配位和随后的手性形成的杂环结构，后一种物质构成了两种非对映异构体的混合物，这些非对映异构体对酸和碱格外稳定。

  DOI：

  10.1016/s0040-4020(01)81096-6

文献信息

• Use of sulfur containing initiators for anionic polymerization of monomers
  申请人：Hogan E. Terrence

  公开号：US20070083023A1

  公开（公告）日：2007-04-12

  An initiator is presented for anionically polymerizing monomers, to provide a functional head group on the polymer. A polymer having a functional head group derived from a sulfur containing anionic initiator, and optionally as additional functional group resulting from the use of a functional terminating reagent, coupling agent or linking agent is also provided. A method is presented for anionically polymerizing monomers comprising the step of polymerizing the monomers with a sulfur containing anionic initiator to provide a functional head group on the polymer. An elastomeric compound, comprising a functional polymer and filler is also described. Also provided is a tire having decreased rolling resistance resulting from a tire component containing a vulcanizable elastomeric compound.

  提供一种用于阴离子聚合单体的引发剂，以在聚合物上提供功能性头基团。还提供了一种聚合物，其具有从含硫阴离子引发剂衍生的功能性头基团，以及可选地由使用功能性终止试剂、偶联剂或连接剂产生的其他功能性基团。提供了一种用于阴离子聚合单体的方法，包括使用含硫阴离子引发剂聚合单体以在聚合物上提供功能性头基团的步骤。还描述了一种弹性化合物，包括功能性聚合物和填料。还提供了一种轮胎，其具有由可硫化弹性化合物组成的轮胎组件，从而导致轮胎滚动阻力降低。
• Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of cns disorders
  申请人：Yamashita Hiroshi

  公开号：US20090264404A1

  公开（公告）日：2009-10-22

  A heterocyclic compound or a salt thereof represented by the formula (1): where R 2 represents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or lower alkenylene group; and R 1 represents an aromatic group or a heterocyclic group. The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.

  一种杂环化合物或其盐，其化学式为（1）：其中R2代表氢原子或较低的烷基基团；A代表较低的烷基烯基基团；R1代表芳香族基团或杂环基团。本发明的化合物具有广泛的治疗精神障碍的谱，包括中枢神经系统障碍，无副作用且安全性高。
• Carbostyril compound
  申请人：Kuroda Takeshi

  公开号：US20070179173A1

  公开（公告）日：2007-08-02

  The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R 4 and R 5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R 1 is a hydrogen atom, etc; R 2 is a hydrogen atom, etc; and R 3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

  本发明提供了一种由通式（1）表示的碳基噻吩化合物或其盐，其中A是直接键，较低的烷基烷基或较低的烷基亚烷基；X是氧原子或硫原子；R4和R5分别表示氢原子；碳基噻吩骨架的3和4位之间的键是单键或双键；R1是氢原子等；R2是氢原子等；R3是氢原子等。本发明的碳基噻吩化合物或其盐能够诱导TFF的产生，因此可用于治疗和/或预防消化道疾病、口腔疾病、上呼吸道疾病、呼吸道疾病、眼部疾病、癌症和伤口等疾病。
• Sulfur containing initiators for anionic polymerization of monomers
  申请人：Hogan E. Terrence

  公开号：US20080004385A1

  公开（公告）日：2008-01-03

  An initiator is presented for anionically polymerizing monomers, to provide a functional head group on the polymer. A polymer having a functional head group derived from a sulfur containing anionic initiator, and optionally as additional functional group resulting from the use of a functional terminating reagent, coupling agent or linking agent is also provided. A method is presented for anionically polymerizing monomers comprising the step of polymerizing the monomers with a sulfur containing anionic initiator to provide a functional head group on the polymer. An elastomeric compound, comprising a functional polymer and filler is also described. Also provided is a tire having decreased rolling resistance resulting from a tire component containing a vulcanizable elastomeric compound.

  提供一种用于阴离子聚合单体的引发剂，以在聚合物上提供一个功能性头基团。提供一种聚合物，其具有从含硫阴离子引发剂衍生的功能性头基团，并且可选地具有由功能性终止试剂、偶联剂或连接剂使用而产生的附加功能性基团。提供一种用于阴离子聚合单体的方法，包括使用含硫阴离子引发剂聚合单体以在聚合物上提供一个功能性头基团。还描述了一种弹性化合物，包括功能性聚合物和填料。还提供了一种轮胎，其具有降低滚动阻力的特性，这是由于轮胎组件中含有可硫化的弹性化合物。
• USE OF SULFUR CONTAINING INITIATORS FOR ANIONIC POLYMERIZATION OF MONOMERS
  申请人：Hogan Terrence E.

  公开号：US20100041797A1

  公开（公告）日：2010-02-18

  A vulcanized rubber composition comprising the vulcanization product of a functional polymer, where the functional polymer is defined by the formula where R is selected from C 1 to C 6 trialkyl-silyl groups, C 1 to C 20 alkyl groups, C 4 to C 20 cycloalkyl groups, C 6 to C 20 aryl groups, thienyl, furyl, and pyridyl groups; and R may optionally have attached thereto any of the following functional groups: C 1 to C 10 alkyl groups, C 6 to C 20 aryl groups, C 2 to C 10 alkenyl groups, C 3 to C 10 non-terminal alkynyl groups, ethers, tert-amines, oxazolines, thiazolines, phosphines, sulfides, silyls, and mixtures thereof; where R 1 is selected from C 2 to C 8 alkylene groups, where X is NR, and where π is a polymer chain.

  一种硫化橡胶组合物，包括功能性聚合物的硫化产物，其中所述功能性聚合物由以下式子定义：其中R选择自C1到C6的三烷基硅基、C1到C20的烷基、C4到C20的环烷基、C6到C20的芳基、噻吩基、呋喃基和吡啶基；R还可以附加以下任何一种功能基团：C1到C10的烷基、C6到C20的芳基、C2到C10的烯基、C3到C10的非端炔基、醚、叔胺、噁唑烷、噻唑烷、膦、硫化物、硅基和其混合物；其中R1选择自C2到C8的烷基，X为NR，π为聚合物链。