N2,N5-Bis(2-hydroxyphenyl)-2,5-pyridinedicarboxamide | 952480-52-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N2,N5-Bis(2-hydroxyphenyl)-2,5-pyridinedicarboxamide
• 英文别名: 2-N,5-N-bis(2-hydroxyphenyl)pyridine-2,5-dicarboxamide
• CAS: 952480-52-3
• 化学式: C₁₉H₁₅N₃O₄
• 分子量: 349.346
• InChiKey: GZLCATRAOKESRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  112
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,5-二吡啶羧酸 、 2-氨基苯酚 在 吡啶 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 N2,N5-Bis(2-hydroxyphenyl)-2,5-pyridinedicarboxamide
  参考文献：
  名称：

  Cytotoxic small molecule dimers and their inhibitory activity against human breast cancer cells

  摘要：

  Small molecules based upon natural product dimers that exhibit cytotoxic activity were synthesized and evaluated for their anti-proliferative activity in human breast cancer cell lines. A central isophthalic core structure linking aromatic amines containing 3,5-disubstitutions produced the most active compounds. This series of compounds was found to be more active against the estrogen receptor positive cell line MCF-7 than the estrogen receptor negative cell line, SKBr3. (C)2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.07.014

文献信息

• Cytotoxic small molecule dimers and their inhibitory activity against human breast cancer cells
  作者：M. Kyle Hadden、Brian S.J. Blagg

  DOI：10.1016/j.bmcl.2007.07.014

  日期：2007.9

  Small molecules based upon natural product dimers that exhibit cytotoxic activity were synthesized and evaluated for their anti-proliferative activity in human breast cancer cell lines. A central isophthalic core structure linking aromatic amines containing 3,5-disubstitutions produced the most active compounds. This series of compounds was found to be more active against the estrogen receptor positive cell line MCF-7 than the estrogen receptor negative cell line, SKBr3. (C)2007 Elsevier Ltd. All rights reserved.