N-[4-[[2,6-bis[(3S,5R)-3,5-diaminopiperidin-1-yl]-7H-purin-8-yl]amino]phenyl]-8-hydroxyquinoline-7-carboxamide | 1041018-93-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-[[2,6-bis[(3S,5R)-3,5-diaminopiperidin-1-yl]-7H-purin-8-yl]amino]phenyl]-8-hydroxyquinoline-7-carboxamide
• CAS: 1041018-93-2
• 化学式: C₃₁H₃₇N₁₃O₂
• 分子量: 623.721
• InChiKey: LHHHMPQKKSEXHH-FGYAAKKASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  46
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  239
• 氢给体数：
  8
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  di-tert-butyl ((3R,5S)-1-(6-((3R,5S)-3,5-bis((tert-butoxycarbonyl)amino)piperidin-1-yl)-8-((4-(8-hydroxyquinoline-7-carboxamido)phenyl)amino)-7H-purin-2-yl)piperidine-3,5-diyl)dicarbamate 在 盐酸 作用下， 以 1,4-二氧六环 、 甲醇 、 水 为溶剂， 生成 N-[4-[[2,6-bis[(3S,5R)-3,5-diaminopiperidin-1-yl]-7H-purin-8-yl]amino]phenyl]-8-hydroxyquinoline-7-carboxamide
  参考文献：
  名称：

  Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors

  摘要：

  Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.04.023

文献信息

• Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors
  作者：Yuefen Zhou、Chun Chow、Douglas E. Murphy、Zhongxiang Sun、Thomas Bertolini、Jamie M. Froelich、Stephen E. Webber、Thomas Hermann、Daniel Wall

  DOI：10.1016/j.bmcl.2008.04.023

  日期：2008.6

  Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa. (C) 2008 Elsevier Ltd. All rights reserved.