6-bromo-4H-indeno[1,2-d][1,3]thiazol-1-ium-2-amine;iodide

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 6-bromo-4H-indeno[1,2-d][1,3]thiazol-1-ium-2-amine;iodide
• 化学式: C₁₀H₇BrN₂S*HI
• 分子量: 395.061
• InChiKey: LEYKJAWHLXUGBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.68
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  67.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-溴茚酮 、 硫脲 在 碘 作用下， 以 乙醇 为溶剂， 以60%的产率得到6-bromo-4H-indeno[1,2-d][1,3]thiazol-1-ium-2-amine;iodide
  参考文献：
  名称：

  2-Aminothiazoles: A new class of agonist allosteric enhancers of A1 adenosine receptors

  摘要：

  This report describes the synthesis and structure-activity relationships of a new class of A(1) adenosine receptor agonist allosteric enhancers, 2-aminothiazolium salts. The EC50 of compounds 6a, 6b, 7, and 8 were 0.3, 4.5, 3.8, and 1.2 muM, substantially lower than that of the 'Gold Standard' 2-amino-3-benzoyl thiophene (PD 81,723), which has an EC50 of 38 muM. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00236-6

文献信息

• 2-Aminothiazole allosteric enhancers of a ?1? adenosine receptors
  申请人：Linden Joel

  公开号：US20050027125A1

  公开（公告）日：2005-02-03

  The present invention relates generally to a class of 2-aminothiazole derivatives which have recently been identified as allosteric enhancers of the A 1? adenosine receptor. These compounds, and therapeutic compositions containing them, are useful for treating conditions in which activation of the A 1? adenosine receptor would be beneficial, for example, those conditions in which stimulation of angiogenesis would improve blood flow to ischemic tissues.

  本发明总体上涉及一类 2-氨基噻唑衍生物，这些衍生物最近被鉴定为 A 1?这些化合物以及含有它们的治疗组合物可用于治疗激活 A 1? 1? 腺苷受体将是有益的，例如，刺激血管生成将改善缺血组织的血流量。
• US7485655B2
  申请人：——

  公开号：US7485655B2

  公开（公告）日：2009-02-03
• 2-Aminothiazoles: A new class of agonist allosteric enhancers of A1 adenosine receptors
  作者：Mahendra D. Chordia、Lauren J. Murphree、Timothy L. Macdonald、Joel Linden、Ray A. Olsson

  DOI：10.1016/s0960-894x(02)00236-6

  日期：2002.6

  This report describes the synthesis and structure-activity relationships of a new class of A(1) adenosine receptor agonist allosteric enhancers, 2-aminothiazolium salts. The EC50 of compounds 6a, 6b, 7, and 8 were 0.3, 4.5, 3.8, and 1.2 muM, substantially lower than that of the 'Gold Standard' 2-amino-3-benzoyl thiophene (PD 81,723), which has an EC50 of 38 muM. (C) 2002 Elsevier Science Ltd. All rights reserved.