2-(4-tert-Butylphenyl)-4,5-dihydro-1H-imidazole | 67277-66-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-tert-Butylphenyl)-4,5-dihydro-1H-imidazole
• CAS: 67277-66-1
• 化学式: C₁₃H₁₈N₂
• 分子量: 202.3
• InChiKey: JRUYKUSXUFPDNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Small Molecule Inhibitors of Botulinum Neurotoxins
  申请人：Bavari Sina

  公开号：US20070112049A1

  公开（公告）日：2007-05-17

  Disclosed herein are methods of inhibiting the activity of Botulinum neurotoxin A metalloprotease with the compounds disclosed herein. Also disclosed are methods of treating, inhibiting or preventing intoxication caused by bacteria of at least one bacterial strain in a subject, and pharmaceutical and cosmetic compositions comprising the compounds disclosed herein.
• Broad Spectrum Antibacterial Compounds
  申请人：Bavari Sina

  公开号：US20070112048A1

  公开（公告）日：2007-05-17

  Disclosed herein are methods of inhibiting, reducing or preventing growth of or destroying bacteria of at least one bacterial strain which comprises contacting the bacteria with the compounds disclosed herein. Also disclosed are methods of treating, inhibiting or preventing an infection or intoxication caused by bacteria of at least one bacterial strain in a subject and pharmaceutical and cosmetic compositions comprising the compounds disclosed herein.
• Antiviral Compounds and Methods of Using Thereof
  申请人：Aman Mohammad Javad

  公开号：US20090012107A1

  公开（公告）日：2009-01-08

  Disclosed herein are compounds which exhibit antiviral activity against a plurality of viruses belonging to different families such as Bornaviridae, Filoviridae, Paramyxoviridae, Rhabdoviridae, Arenaviridae, Bunyaviridae, Orthomyxoviridae, and Poxviridae. Thus, methods of preventing, inhibiting, or reducing the viral activity of various viruses are provided as well as methods of treating viral infections.
• METHOHDS OF INHIBITING VIRAL INFECTION
  申请人：Kinch Michael

  公开号：US20090170890A1

  公开（公告）日：2009-07-02

  A method of inhibiting viral infection in a mammal in need of same, includes administering an effective amount of at least one of the compounds of FGI-103 which are represented by 273, 365 and 510 either prophylactically to prevent viral infection, or therapeutically following viral infection. These compounds appear to selectively inhibit Caspase 8 as a method of preventing infective viral particle release. They can be administered IV, IP, orally or via other conventional administration routes. The compounds are highly effective, requiring relatively low dosages on the order of 1 ng/kg-200 mg/kg of body weight.
• US7825154B2
  申请人：——

  公开号：US7825154B2

  公开（公告）日：2010-11-02