2-[(aminocarbonyl)amino]-5-[4-{([3-(trifluoromethyl)benzyl]amino)methyl}phenyl]thiophene-3-carboxamide | 728947-90-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(aminocarbonyl)amino]-5-[4-{([3-(trifluoromethyl)benzyl]amino)methyl}phenyl]thiophene-3-carboxamide
• 英文别名: 2-(Carbamoylamino)-5-[4-[[[3-(trifluoromethyl)phenyl]methylamino]methyl]phenyl]thiophene-3-carboxamide
• CAS: 728947-90-8
• 化学式: C₂₁H₁₉F₃N₄O₂S
• 分子量: 448.469
• InChiKey: LZWDGWLXJSDOCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  139
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] THIOPHENE-CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZIME IKK-2<br/>[FR] DERIVES DE THIOPHENE-CARBOXAMIDE ET LEUR UTILISATION COMME INHIBITEURS DE L'ENZYME IKK-2
  申请人：ASTRAZENECA AB

  公开号：WO2004063186A1

  公开（公告）日：2004-07-29

  The invention relates to thiophene carboxamides of formula (I), wherein A, R1, R2, R3, R4, R5 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy .

  该发明涉及式(I)的噻吩羧酰胺，其中A、R1、R2、R3、R4、R5和X如规范中所定义，以及在其制备过程中使用的中间体，含有它们的药物组合物以及它们在治疗中的应用。
• Thiophene-carboxamide derivatives and their use as inhibitors of the enzyme ikk-2
  申请人：Faull Wellington Alan

  公开号：US20060058522A1

  公开（公告）日：2006-03-16

  The invention relates to thiophene carboxamides of formula (I), wherein A, R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及式(I)的噻吩羧酰胺，其中A、R1、R2、R3、R4、R5和X如说明书中所定义，以及用于其制备的过程和中间体、含有它们的制药组合物以及它们在治疗中的使用。
• THIOPHENE-CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2
  申请人：Faull Alan Wellington

  公开号：US20100029754A1

  公开（公告）日：2010-02-04

  The invention relates to thiophene carboxamides of formula (I), wherein A, R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及式(I)的噻吩羧酰胺，其中A、R1、R2、R3、R4、R5和X如规范中所定义，以及用于其制备的过程和中间体，含有它们的药物组合物以及它们在治疗中的使用。
• THIOPHENE-CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZIME IKK-2
  申请人：AstraZeneca AB

  公开号：EP1583755A1

  公开（公告）日：2005-10-12
• US7572826B2
  申请人：——

  公开号：US7572826B2

  公开（公告）日：2009-08-11