O-(6'-amino-[2,2']bipyridinyl-5-ylmethyl)-hydroxylamine | 628704-31-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: O-(6'-amino-[2,2']bipyridinyl-5-ylmethyl)-hydroxylamine
• 英文别名: O-[[6-(6-aminopyridin-2-yl)pyridin-3-yl]methyl]hydroxylamine
• CAS: 628704-31-4
• 化学式: C₁₁H₁₂N₄O
• 分子量: 216.242
• InChiKey: UAEOBJGXVWQSKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  87
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  、 O-(6'-amino-[2,2']bipyridinyl-5-ylmethyl)-hydroxylamine 在 盐酸 作用下， 以 水 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  WO2007/115278

  摘要：

  公开号：

文献信息

• 9N-substituted 6-11 bicyclic erythromycin derivatives
  申请人：Qiu Yao-Ling

  公开号：US20050171033A1

  公开（公告）日：2005-08-04

  The present invention discloses compounds of formula I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

  本发明揭示了公式I、II、III或IV的化合物，或其外消旋体、对映异构体、位置异构体、盐、酯或前药：其具有抗菌性质。本发明还涉及包含上述化合物的制药组合物，用于治疗需要抗生素治疗的受试者。本发明还涉及通过给予含有本发明化合物的制药组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。
• US7265094B2
  申请人：——

  公开号：US7265094B2

  公开（公告）日：2007-09-04
• [EN] 9N-SUBSTITUTED 6-11 BICYCLIC ERYTHROMYCIN DERIVATIVES<br/>[FR] DERIVES D'ERYTHROMYCINE BICYCLIQUES 9-N SUBSTITUES EN C6-C11
  申请人：ENANTA PHARM INC

  公开号：WO2005070113A2

  公开（公告）日：2005-08-04

  The present invention discloses compounds of formula (I), (II), (III), or (IV), or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: formulas (I), (II), (III), (IV), which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
• [EN] 3,6,11-TRICYCLOLIDE<br/>[FR] 3,6,11-TRICYCLOLIDE
  申请人：ENANTA PHARM INC

  公开号：WO2007115278A2

  公开（公告）日：2007-10-11

  [EN] The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof, which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
  [FR] La présente invention concerne des composés de formule (I) ou des sels, esters ou promédicaments pharmaceutiquement acceptables de ceux-ci, lesquels présentent des propriétés antibactériennes. La présente invention concerne également des compositions pharmaceutiques comprenant les composés susmentionnés, destinées à être administrées à un sujet nécessitant une antibiothérapie. L'invention concerne également des procédés visant à traiter une infection bactérienne chez un sujet, consistant en l'administration d'une composition pharmaceutique comprenant les composés de la présente invention. Par ailleurs, des procédés de fabrication des composés selon cette invention sont également décrits.