5-chloro-6-methyl-2-[1-[(2-methylpropan-2-yl)oxycarbonyl]-3,6-dihydro-2H-pyridin-4-yl]pyridine-3-carboxylic acid | 934361-42-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-chloro-6-methyl-2-[1-[(2-methylpropan-2-yl)oxycarbonyl]-3,6-dihydro-2H-pyridin-4-yl]pyridine-3-carboxylic acid
• CAS: 934361-42-9
• 化学式: C₁₇H₂₁ClN₂O₄
• 分子量: 352.818
• InChiKey: BLYNYWKTAAHCKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  79.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-chloro-6-methyl-2-[1-[(2-methylpropan-2-yl)oxycarbonyl]-3,6-dihydro-2H-pyridin-4-yl]pyridine-3-carboxylic acid 在 碘 、 碳酸氢钠 、 potassium iodide 作用下， 以 水 、 乙腈 为溶剂， 反应 18.0h， 以85%的产率得到Tert-butyl 3-chloro-3'-iodo-2-methyl-5-oxospiro[furo[3,4-b]pyridine-7,4'-piperidine]-1'-carboxylate
  参考文献：
  名称：

  Preparation of 3,4-fused-spiro[furan-5(5H),4′-piperidin]-2-one

  摘要：

  A general method for the preparation of various 3,4-fused-spiro[furan-5(5H),4'-piperidini-2-one with high yield is reported. The formation of spiro[furarione-piperidine] structure was achieved by a Suzuki coupling, followed by an iodolactonization reaction. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.035
• 作为产物：
  描述：

  methyl 5-chloro-6-methyl-2-[1-[(2-methylpropan-2-yl)oxycarbonyl]-3,6-dihydro-2H-pyridin-4-yl]pyridine-3-carboxylate 在 甲醇 、 sodium hydroxide 、 水 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 生成 5-chloro-6-methyl-2-[1-[(2-methylpropan-2-yl)oxycarbonyl]-3,6-dihydro-2H-pyridin-4-yl]pyridine-3-carboxylic acid
  参考文献：
  名称：

  [EN] ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS
  [FR] DERIVES SPIROPIPERIDINES ACYLES CONVENANT COMME MODULATEURS DES RECEPTEURS DE LA MELANOCORTINE-4

  摘要：

  公开号：

  WO2007041052A3

文献信息

• [EN] ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS<br/>[FR] DERIVES SPIROPIPERIDINES ACYLES CONVENANT COMME MODULATEURS DES RECEPTEURS DE LA MELANOCORTINE-4
  申请人：MERCK & CO INC

  公开号：WO2007041052A3

  公开（公告）日：2007-05-31
• ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP1940842B1

  公开（公告）日：2012-05-30
• Acylated Spiropiperidine Derivatives as Melanocortin-4 Receptor Modulators
  申请人：Jian Tianying

  公开号：US20090170863A1

  公开（公告）日：2009-07-02

  Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
• US8293900B2
  申请人：——

  公开号：US8293900B2

  公开（公告）日：2012-10-23
• Preparation of 3,4-fused-spiro[furan-5(5H),4′-piperidin]-2-one
  作者：Jian Liu、Tianying Jian、Liangqin Guo、Tzvetomira Atanasova、Ravi P. Nargund

  DOI：10.1016/j.tetlet.2009.07.035

  日期：2009.9

  A general method for the preparation of various 3,4-fused-spiro[furan-5(5H),4'-piperidini-2-one with high yield is reported. The formation of spiro[furarione-piperidine] structure was achieved by a Suzuki coupling, followed by an iodolactonization reaction. (C) 2009 Elsevier Ltd. All rights reserved.