4-Pyridinecarboxaldehyde, 2,5-dichloro-, oxime | 102645-34-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-Pyridinecarboxaldehyde, 2,5-dichloro-, oxime
• 英文别名: N-[(2,5-dichloropyridin-4-yl)methylidene]hydroxylamine
• CAS: 102645-34-1
• 化学式: C₆H₄Cl₂N₂O
• 分子量: 191.017
• InChiKey: HWJZBZVZTUBERC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-Pyridinecarboxaldehyde, 2,5-dichloro-, oxime 在 盐酸 作用下， 以 异丙醇 为溶剂， 以94%的产率得到2,5-二氯异烟腈
  参考文献：
  名称：

  2-Amino-5-aryl-pyridines as selective CB2 agonists: Synthesis and investigation of structure–activity relationships

  摘要：

  2-Amino-5-aryl-pyridines, exemplified by compound 1, had been identified as a synthetically tractable series of CB2 agonists from a high-throughput screen of the GlaxoSmithKline compound collection. Described herein are the results of an investigation of the structure-activity relationships (SAR) which led to the identification a number of potent and selective agonists. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.041
• 作为产物：
  描述：

  2,5-二氯吡啶-4-醛 在 盐酸羟胺 作用下， 生成 4-Pyridinecarboxaldehyde, 2,5-dichloro-, oxime
  参考文献：
  名称：

  2-Amino-5-aryl-pyridines as selective CB2 agonists: Synthesis and investigation of structure–activity relationships

  摘要：

  2-Amino-5-aryl-pyridines, exemplified by compound 1, had been identified as a synthetically tractable series of CB2 agonists from a high-throughput screen of the GlaxoSmithKline compound collection. Described herein are the results of an investigation of the structure-activity relationships (SAR) which led to the identification a number of potent and selective agonists. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.041

文献信息

• Certain phenoxy-pyridine-carbonitriles having antiviral activity
  申请人：The Dow Chemical Company

  公开号：US04558134A1

  公开（公告）日：1985-12-10

  Substituted pyridines exhibiting antiviral activity are disclosed. Also disclosed are methods of use involving the substituted pyridines as well as compositions comprising a non-toxic, pharmaceutically-acceptable carrier in combination with one or more said substituted pyridines.

  本发明揭示了具有抗病毒活性的取代吡啶。本发明还揭示了使用所述取代吡啶的方法，以及包含一种非毒性、药学上可接受的载体与一种或多种所述取代吡啶的组合物。