4-[(3-aminophenyl)[1-(2-methoxyethyl)-4-piperidinylidene]methyl]-N,N-diethyl-benzamide | 859911-37-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(3-aminophenyl)[1-(2-methoxyethyl)-4-piperidinylidene]methyl]-N,N-diethyl-benzamide
• 英文别名: 4-[(3-aminophenyl)-[1-(2-methoxyethyl)piperidin-4-ylidene]methyl]-N,N-diethylbenzamide
• CAS: 859911-37-8
• 化学式: C₂₆H₃₅N₃O₂
• 分子量: 421.583
• InChiKey: HHLQRUMQBIIZCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  58.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF<br/>[FR] DERIVES DE DIARYLMETHYLIDENE PIPERIDINE, PREPARATIONS A BASE DE CES DERIVES ET PROCEDES DE LEUR UTILISATION
  申请人：ASTRAZENECA AB

  公开号：WO2005066127A1

  公开（公告）日：2005-07-21

  Compounds of formula: wherein R1, R2, and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

  其中R1、R2和R3如规范中定义的化合物，以及其盐、对映体和包括这些化合物的药物组合物已经准备好。它们在治疗中很有用，特别是在疼痛管理中。
• DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF
  申请人：AstraZeneca AB

  公开号：EP1706379A1

  公开（公告）日：2006-10-04
• Diarylmethylidene Piperidine Derivatives, Preparations Thereof and Uses Thereof
  申请人：Brown William

  公开号：US20070219249A1

  公开（公告）日：2007-09-20

  Compounds of formula: wherein R 1 , R 2 , and R 3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.