3-[(2-amino)pyrimidin-4-yl]-4-(cyclohexylmethoxy)-1H-pyrrolo[2,3-b]pyridine | 1048966-77-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 3-[(2-amino)pyrimidin-4-yl]-4-(cyclohexylmethoxy)-1H-pyrrolo[2,3-b]pyridine
• 英文别名: 4-[4-(cyclohexylmethoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
• CAS: 1048966-77-3
• 化学式: C₁₈H₂₁N₅O
• 分子量: 323.398
• InChiKey: KKPULEBJQJSKFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  89.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• PYRROLO[2,3-B]PYRIDINE COMPOUNDS, AZAINDOLE COMPOUNDS USED FOR SYNTHESIZING SAID PYRROLO[2,3-B]PYRIDINE COMPOUNDS, METHODS FOR THE PRODUCTION THEREOF, AND USES THEREOF
  申请人：Meijer Laurent

  公开号：US20100184790A1

  公开（公告）日：2010-07-22

  The invention relates to pyrrolo[2,3-b]pyridine compounds and azaindole compounds used for the synthesis thereof. The invention also relates to methods for the production thereof and the uses thereof. Said novel pyrrolo[2,3-b]pyridine compounds according to the invention have great antiproliferative, apoptotic, and neuroprotective activities. The invention particularly applies to the pharmaceutical field.

  该发明涉及用于合成吡咯并[2,3-b]吡啶化合物和氮杂吲哚化合物的方法。该发明还涉及其生产方法和用途。根据该发明，所述新型吡咯并[2,3-b]吡啶化合物具有很强的抗增殖、凋亡和神经保护活性。该发明特别适用于药物领域。
• COMPOSES PYRROLO[2,3-B]PYRIDINE, COMPOSES AZAINDOLES UTILES DANS LA SYNTHESE DE CES COMPOSES PYRROLO[2,3-B]PYRIDINE, LEURS PROCEDES DE FABRICATION ET LEURS UTILISATIONS
  申请人：Centre National de la Recherche Scientifique

  公开号：EP2125803B1

  公开（公告）日：2013-04-10
• [EN] PYRROLO[2,3-B]PYRIDINE COMPOUNDS, AZAINDOLE COMPOUNDS USED FOR SYNTHESIZING SAID PYRROLO[2,3-B]PYRIDINE COMPOUNDS, METHODS FOR THE PRODUCTION THEREOF, AND USES THEREOF<br/>[FR] COMPOSES PYRROLO[2,3-B]PYRIDINE, COMPOSES AZAINDOLES UTILES DANS LA SYNTHESE DE CES COMPOSES PYRROLO[2,3-B]PYRIDINE, LEURS PROCEDES DE FABRICATION ET LEURS UTILISATIONS
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2008129152A1

  公开（公告）日：2008-10-30

  [EN] The invention relates to pyrrolo[2,3-b]pyridine compounds and azaindole compounds used for the synthesis thereof. The invention also relates to methods for the production thereof and the uses thereof. Said novel pyrrolo[2,3-b]pyridine compounds according to the invention have great antiproliferative, apoptotic, and neuroprotective activities. The invention particularly applies to the pharmaceutical field.
  [FR] L'invention concerne des composés pyrrolo[2,3-b]pyridine ainsi que des composés azaindoles utiles dans leur synthèse. Elle concerne également leurs procédés de fabrication et leurs utilisations. Les nouveaux composés pyrrolo[2,3-b]pyridine de l'invention ont des activités antiprolifératives, apoptotiques et neuroprotectives puissantes. L'invention trouve application en particulier dans le domaine de la pharmacie.