2-carbamoyl-3-(4-nitro-phenyl)-oxiranecarboxylic acid ethyl ester | 13942-47-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-carbamoyl-3-(4-nitro-phenyl)-oxiranecarboxylic acid ethyl ester
• 英文别名: Ethyl 2-carbamoyl-3-(4-nitrophenyl)oxirane-2-carboxylate
• CAS: 13942-47-7
• 化学式: C₁₂H₁₂N₂O₆
• 分子量: 280.237
• InChiKey: JWPIKQOPRDBWFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  128
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Oxiranecarboxylic acid ester derivatives, their preparation and their inclusion in lipogenesis inhibiting compositions
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0018682A1

  公开（公告）日：1980-11-12

  This invention relates to oxiranecarboxylic acid ester derivatives. There are provided 3-substituted-2-(aminocarbonyl) oxiranecarboxylic acid esters of formula wherein R is phenyl substituted by one or two groups independently selected from nitro and alkoxy or is benzoyl, R' is alkyl, alkenyl, alkynyl or cycloalkyl, R' and R2 are each independently hydrogen, alkyl, alkenyl, alkynyl or cycloalkyl or R' and R2together represent an alkylene chain containing four or five carbon atoms; processes for their preparation; lipogenesis-inhibiting compositions containing them and the preparation of such compositions. Oxirane carboxylic acid ester derivatives of formula I have exhibited lipogenesis inhibiting activity.

  本发明涉及环氧乙烷羧酸酯衍生物。 提供了式 3-取代-2-（氨基羰基）环氧乙烷羧酸酯 其中 R 是被一个或两个独立选自硝基和烷氧基的基团取代的苯基或苯甲酰基，R'是烷基、烯基、炔基或环烷基，R'和 R2 各自独立地是氢、烷基、烯基、炔基或环烷基，或 R' 和 R2 共同代表含有四个或五个碳原子的亚烷基链；其制备工艺；含有它们的脂肪生成抑制组合物和这种组合物的制备方法。 式 I 的环氧乙烷羧酸酯衍生物具有抑制脂肪生成的活性。