N-[2-[4-(benzhydryloxy)piperidino]ethyl]-3-hydroxy-5-(3-pyridylmethoxy)-2-naphthamide | 143964-80-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-[4-(benzhydryloxy)piperidino]ethyl]-3-hydroxy-5-(3-pyridylmethoxy)-2-naphthamide
• 英文别名: F-1322；N-[2-[4-(benzhydryloxy)piperidino]ethyl]-3-hydroxy-5-(pyridin-3-ylmethoxy)-2-naphthamide；Unii-2K83jyy5S9；N-[2-(4-benzhydryloxypiperidin-1-yl)ethyl]-3-hydroxy-5-(pyridin-3-ylmethoxy)naphthalene-2-carboxamide
• CAS: 143964-80-1
• 化学式: C₃₇H₃₇N₃O₄
• 分子量: 587.718
• InChiKey: ZBOYHAZRFJBUEL-UHFFFAOYSA-N

物化性质

• 沸点：
  793.6±60.0 °C(Predicted)
• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  44
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  83.9
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-(4-benzhydryloxy-piperidin-1-yl)-ethylamine 、 methyl 3-hydroxy-5-(pyridin-3-ylmethoxy)-2-naphthoate 以 水 、 甲苯 为溶剂， 以5.22 g (91%)的产率得到N-[2-[4-(benzhydryloxy)piperidino]ethyl]-3-hydroxy-5-(3-pyridylmethoxy)-2-naphthamide
  参考文献：
  名称：

  Method of producing 2-naphthamide derivative, and compounds for

  摘要：

  提供了一种生产2-萘酰胺衍生物的方法（式（I）），该衍生物可用作抗过敏剂或治疗过敏症的药剂，以及用于生产2-萘酰胺衍生物的化合物：##STR1##其中R.sup.1和R.sup.2分别是未取代或取代的芳香族碳氢基团或未取代或取代的芳香族杂环基团；R.sup.3是酰基，烷氧羰基基团，取代的氨基甲酰基团或未取代或取代的烷基基团。

  公开号：

  US05714613A1

文献信息

• Naphthoic acid derivative
  申请人：Fujirebio Inc.

  公开号：US05324728A1

  公开（公告）日：1994-06-28

  A naphthoic acid derivative represented by the following general formula or a salt thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkanoyloxy-lower alkyl group or an aralkyloxy group; R.sub.4 is a hydrogen atom or a lower alkyl group; R.sub.5 is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaromatic group; X is a group ##STR2## a cycloalkylene group, a bivalent nitrogen-containing heterocyclic group, or a group ##STR3## --R.sub.8 --NH-- or --NH--R.sub.8, where R.sub.6 and R.sub.7 are each a hydrogen atom or a lower alkyl group and R.sub.8 is a cycloalkylene group, or R.sub.6 and R.sub.7, together with R.sub.4, may form an alkylene group of 1-3 carbon atoms; Y is --S(O).sub.p --, --(CH.sub.2).sub.n -- or --O--; Z is a substituted or unsubstituted alkylene group or a single bond; l is an integer of 0-4; m is an integer of 0-8; n is 0 or 1; p is an integer of 0-2; and g is 0 or 1. The compound is useful as an antiallergic agent.

  以下是一种萘酸衍生物或其盐的通式：##STR1##其中，R.sub.1、R.sub.2和R.sub.3各自独立地是氢原子、卤素原子、羟基、低烷基、低烷氧基、低酰氧基、羟基-低烷基、低烷氧基-低烷基、低酰氧基-低烷基或芳基烷氧基；R.sub.4是氢原子或低烷基；R.sub.5是取代或未取代芳基或取代或未取代杂环芳基；X是一个基团##STR2##一个环烷基基团、一个含氮杂环的双价基团或一个基团##STR3##--R.sub.8 --NH--或--NH--R.sub.8，其中R.sub.6和R.sub.7各自是氢原子或低烷基，R.sub.8是环烷基，或R.sub.6和R.sub.7与R.sub.4一起可以形成1-3个碳原子的烷基；Y是--S(O).sub.p --、--(CH.sub.2).sub.n --或--O--；Z是取代或未取代的烷基或单键；l是0-4的整数；m是0-8的整数；n是0或1；p是0-2的整数；g是0或1。该化合物可用作抗过敏药物。
• AGENT FOR PREVENTION AND DEPRESSION OF DRY COUGHING CAUSED BY ANGIOTENSIN CONVERTING ENZYME INHIBITORS
  申请人：KISSEI PHARMACEUTICAL CO., LTD.

  公开号：EP0875254A1

  公开（公告）日：1998-11-04

  The present invention is to provide an agent for the prevention and depression of dry coughing caused by angiotensin converting enzyme inhibitors which comprises a thromboxane synthetase inhibitor or thromboxane receptor antagonist as the active ingredient. Administering the drug is effective in preventing and depressing dry coughing caused by angiotensin converting enzyme inhibitors. For example, the use of the drug in combination with ozagrel hydrochloride was found to be effective in significantly dry coughing in hypertonic patients suffering from dry coughing attributable to the administration of captopril.

  本发明旨在提供一种预防和抑制由血管紧张素转换酶抑制剂引起的干咳的药物，其活性成分包括血栓素合成酶抑制剂或血栓素受体拮抗剂。服用该药物可有效预防和抑制血管紧张素转换酶抑制剂引起的干咳。例如，对于因服用卡托普利而引起干咳的高渗患者，将该药物与盐酸奥扎格雷联合使用可有效明显缓解干咳。
• Combination for the treatment of airway disorders
  申请人：Hanauer Guido

  公开号：US20050165041A1

  公开（公告）日：2005-07-28

  The invention relates to the combination of proton pump inhibitors and airway therapeutics for the treatment of airway disorders.

  本发明涉及质子泵抑制剂和气道治疗剂的组合，用于治疗气道疾病。
• Method of producing 2-naphthamide derivative, and compounds for producing 2-naphthamide derivative
  申请人：FUJIREBIO Inc.

  公开号：EP0747369B1

  公开（公告）日：2000-05-03
• NEW COMBINATION OF REVERSIBLE PROTON PUMP INHIBITORS AND AIRWAY THERAPEUTICS FOR TREATING AIRWAY DISORDERS
  申请人：ALTANA Pharma AG

  公开号：EP1506016A2

  公开（公告）日：2005-02-16