4-cyano-N-(5-(5-(trifluoromethyl)-1.2.4-oxadiazol-3-yl)pyrazin-2-yl)benzamide | 1441872-48-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-cyano-N-(5-(5-(trifluoromethyl)-1.2.4-oxadiazol-3-yl)pyrazin-2-yl)benzamide
• 英文别名: US9670193, 2 4-Cyano-N-(5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyrazin-2-yl)benzamide；4-cyano-N-[5-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]pyrazin-2-yl]benzamide
• CAS: 1441872-48-5
• 化学式: C₁₅H₇F₃N₆O₂
• 分子量: 360.255
• InChiKey: NAMQOOWUSQEAMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• [EN] NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE<br/>[FR] NOUVEAUX DÉRIVÉS TRIFLUOROMÉTHYL-OXADIAZOLES ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES
  申请人：NOVARTIS AG

  公开号：WO2013080120A1

  公开（公告）日：2013-06-06

  The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical combinations thereof, and their use as medicaments, particularly for the treatment of neurodegeneration, muscle atrophy or diabetes/metabolic syndrome via inhibition of HDAC4.

  该发明涉及一种新型三氟甲基-噁二唑衍生物的公式(I)，以及其药学上可接受的盐，其中所有变量均如规范中定义，其药物组合物，药物组合物及其作为药物的用途，特别用于通过抑制HDAC4治疗神经退行性疾病、肌肉萎缩或糖尿病/代谢综合征。
• [EN] SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI<br/>[FR] OXADIAZOLES SUBSTITUÉS POUR LUTTER CONTRE DES CHAMPIGNONS PHYTOPATHOGÈNES
  申请人：BASF SE

  公开号：WO2017081310A1

  公开（公告）日：2017-05-18

  The present invention relates to novel oxadiazoles of the formula (I), or the N-oxides and/or their agriculturally useful salts and to their use for controlling phytopathogenic fungi, or to a method for combating phytopathogenic harmful fungi, which process comprises treating the fungi or the materials, plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of the formula (I), or an N-oxide, or an agriculturally acceptable salt thereof; the present invention also relates to mixtures comprising at least one such compound of the formula (I) and at least one further pesticidally active substance selected from the group consisting of herbicides, safeners, fungicides, insecticides, and plant growth regulators; and to agrochemical compositions comprising at least one such compound of the formula I and to agrochemical compositions further comprising seeds.

  本发明涉及公式（I）的新型噁二唑，或其N-氧化物和/或其农业上有用的盐，以及它们用于控制植物病原真菌或对抗植物病原真菌的方法，该方法包括使用公式（I）中至少一种化合物、N-氧化物或其农业上可接受的盐的有效量处理真菌或要保护免受真菌攻击的材料、植物、土壤或种子；本发明还涉及混合物，包括至少一种公式（I）的化合物和至少一种来自除草剂、安全剂、杀菌剂、杀虫剂和植物生长调节剂组的其他杀虫活性物质；以及包括至少一种公式（I）的农药组合物和进一步包括种子的农药组合物。
• NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
  申请人：Hebach Christina

  公开号：US20140329825A1

  公开（公告）日：2014-11-06

  The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical combinations thereof, and their use as medicaments, particularly for the treatment of neurodegeneration, muscle atrophy or diabetes/metabolic syndrome via inhibition of HDAC4.

  本发明涉及一种新型三氟甲基-噁二唑衍生物，其化学式为（I），以及其药物可接受的盐。其中所有变量如规范所定义，包括其制药组合物、制药组合物的药物组成物以及它们作为药物的用途，特别是通过抑制HDAC4治疗神经退行性、肌肉萎缩或糖尿病/代谢综合征。
• SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI
  申请人：BASF SE

  公开号：EP3373732A1

  公开（公告）日：2018-09-19
• US9670193B2
  申请人：——

  公开号：US9670193B2

  公开（公告）日：2017-06-06