2-(3-Methylpyridin-2-yl)acetic acid hydrochloride | 1609395-45-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(3-Methylpyridin-2-yl)acetic acid hydrochloride
• 英文别名: 2-(3-methylpyridin-2-yl)acetic acid;hydrochloride
• CAS: 1609395-45-0
• 化学式: C8H10ClNO2
• mdl: MFCD28024799
• 分子量: 187.62
• InChiKey: JIEJZPKLYBSNHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  50.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3-Methylpyridin-2-yl)acetic acid hydrochloride 、 (2-(2,2,2-trifluoroethoxy)pyridin-4-yl)methanamine 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 以11 %的产率得到2-(3-methylpyridin-2-yl)-N-((2-(2,2,2-trifluoroethoxy)pyridin-4-yl)methyl)acetamide
  参考文献：
  名称：

  AMIDE COMPOUNDS AS ACTIVATORS OF THE POTASSIUM CHANNELS KV7.2/KV7.3 USEFUL IN THE TREATMENT OF CNS AND PNS DISORDERS

  摘要：

  The present invention relates to compounds of formula (I) as defined in the specification capable of promoting the opening of Kv7.2/Kv7.3 potassium channels, a pharmaceutical composition comprising them, and their use as a drug, particularly in the treatment of disorders of the central nervous system (CNS), such as, for example, epilepsy and neurodegenerative disorders, and of the peripheral nervous system (PNS), such as, for example, chronic and neuropathic pain.

  公开号：

  WO2024121046A1