2-Chlor-3.4.5.6-tetramethylpyridin | 31824-82-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Chlor-3.4.5.6-tetramethylpyridin
• 英文别名: 3,4,5,6-Tetramethyl-2-chlor-pyridin；2-chloro-3,4,5,6-tetramethyl-pyridine；2-Chloro-3,4,5,6-tetramethylpyridine
• CAS: 31824-82-5
• 化学式: C₉H₁₂ClN
• 分子量: 169.654
• InChiKey: NQRMLXOCMRALQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,3,4,5-四甲基吡咯 、 氯仿 以26%的产率得到
  参考文献：
  名称：

  BUSBY R. E.; IGBAL M.; KHAN M. A.; PARRICK J.; SHAW C. J. G., J. CHEM. SOC. PERKIN TRANS. PART 1, 1979, NO 6, 1578-1582

  摘要：

  DOI：

文献信息

• SPIROCYCLIC AZAADAMANTANE DERIVATIVES AND METHODS OF USE
  申请人：Ji Jianguo

  公开号：US20080153860A1

  公开（公告）日：2008-06-26

  The invention relates to compounds that are spirocyclic azaadamantane derivatives derivatives, particularly spirocyclic azaadamantanyl ether or amine derivatives, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.

  这项发明涉及螺环状氮杂金刚烷衍生物，特别是螺环状氮杂金刚烷基醚或胺衍生物，包括这些化合物的组合物，使用这些化合物和组合物的方法，制备这些化合物的过程，以及在这些过程中获得的中间体。
• Process for Preparing 5-Fluoro-1H-Pyrazolo [3,4-b] Pyridin-3-amine and Derivatives Thereof
  申请人：Jimenez Juan-Miguel

  公开号：US20100184980A1

  公开（公告）日：2010-07-22

  The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.

  本发明涉及一种高产率和纯度的合成5-氟-1H-吡唑并[3,4-b]吡啶-3-胺的方法。本发明还涉及合成5-氟-1H-吡唑并[3,4-b]吡啶-3-胺衍生物的方法。这些方法可用于制备生物活性化合物，特别是某些GSK-3抑制剂或其衍生物。
• PYRIMIDINES AND PYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES
  申请人：Henkel Gregory William

  公开号：US20110224197A1

  公开（公告）日：2011-09-15

  The present invention relates to compounds useful as inhibitors of protein kinases, such as inhibitors of GSK-3. The invention provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. The invention provides processes for preparing compounds of the invention. The invention provides methods of identifying compounds useful for treatment of diabetes, diabetic neuropathy, osteoporosis, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, bipolar disorder, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, leukocytopenia, cardiomyocyte hypertrophy, stroke, post-stroke, spinal cord injury, traumatic brain injury, Charcot-Marie-Tooth, peripheral nerve regeneration, and rheumatoid arthritis.

  本发明涉及一种作为蛋白激酶抑制剂的化合物，例如GSK-3的抑制剂。本发明提供了包含本发明化合物的药学上可接受的组合物，并提供了使用这些组合物治疗各种疾病的方法。本发明提供了制备本发明化合物的方法。本发明提供了鉴定用于治疗糖尿病、糖尿病神经病变、骨质疏松症、阿尔茨海默病、亨廷顿病、帕金森病、艾滋病相关痴呆、双相情感障碍、肌萎缩性侧索硬化、多发性硬化症、精神分裂症、白细胞减少症、心肌细胞肥大、中风、中风后、脊髓损伤、创伤性脑损伤、沙科-玛丽-图特病、周围神经再生和类风湿性关节炎的化合物的方法。
• PROCESS FOR PREPARING 5-FLUORO-1H-PYRAZOLO [3,4-B] PYRIDIN-3-AMINE AND DERIVATIVES THEREOF
  申请人：Jimenez Juan-Miguel

  公开号：US20120232275A1

  公开（公告）日：2012-09-13

  The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.

  本发明涉及一种高收率和高纯度合成5-氟-1H-吡唑并[3,4-b]吡啶-3-胺的方法。本发明还涉及合成5-氟-1H-吡唑并[3,4-b]吡啶-3-胺衍生物的方法。这些方法有助于制备生物活性化合物，特别是某些GSK-3抑制剂或其衍生物。
• NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS.
  申请人：Galapagos NV

  公开号：US20150005275A1

  公开（公告）日：2015-01-01

  The present invention discloses compounds according to Formula I: wherein R 1 , R 2 , R 3 , L, and the subscript m are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions, and methods of treatment using the same, for the treatment of cystic fibrosis by administering a compound of the invention.

  本发明公开了式I的化合物：其中R1、R2、R3、L和下标m的定义如本文所述。本发明涉及这些化合物及其在囊性纤维化治疗中的应用，以及它们的生产方法、制药组合物和使用相同的治疗方法，通过给予该发明的化合物治疗囊性纤维化。