Tussionex | 131219-97-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Tussionex
• 英文别名: (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
• CAS: 131219-97-1
• 化学式: C34H40ClN3O3
• 分子量: 574.1
• InChiKey: UUEZOEBHFHYMGR-RNWHKREASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.75
• 重原子数：
  41
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  54.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] PYRIDAZINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER<br/>[FR] DÉRIVÉS DE PYRIDAZINONE ET LEUR UTILISATION DANS LE TRAITEMENT DU CANCER
  申请人：GENENTECH INC

  公开号：WO2016112298A1

  公开（公告）日：2016-07-14

  The invention relates to compounds of formula (I) and salts thereof: wherein R1-R3 have any of the values defined in the specification. The compounds and salts are useful for treating PCAF mediated disorders and/or GCN5 mediated disorders. The invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, as well as and methods of using said compounds, salts, or compositions in the treatment of various disorders.

  该发明涉及公式（I）的化合物及其盐：其中R1-R3具有规范中定义的任何值。这些化合物和盐对于治疗由PCAF介导的疾病和/或由GCN5介导的疾病是有用的。该发明还提供了包括公式（I）的化合物或其药学上可接受的盐的药物组合物，以及使用所述化合物、盐或组合物治疗各种疾病的方法。
• HALF IMMUNOGLOBULIN BINDING PROTEINS AND USES THEREOF
  申请人：AbbVie Inc.

  公开号：EP2654792A2

  公开（公告）日：2013-10-30
• PYRIDAZINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER
  申请人：Genentech, Inc.

  公开号：EP3242874A1

  公开（公告）日：2017-11-15
• METHOD AND APPARATUS FOR PACKAGING AND DISPENSING PHARMACEUTICALS
  申请人：Tramonte Arturo

  公开号：US20110240504A1

  公开（公告）日：2011-10-06

  A method of packaging one or more pharmaceuticals comprising separating a plurality of unit doses into a plurality of unit dose compartments, wherein each unit dose compartment of the plurality of unit dose compartments holds only one unit dose of the plurality of unit doses, each unit dose having the same strength, wherein the plurality of unit doses is precisely a quantity equal to a most commonly prescribed number of unit doses in individual prescriptions for the unit dose, or a multiple thereof is provided. Also provided are kits prepared by the method. Methods for designing such kits and packaging are also provided.
• [EN] METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION<br/>[FR] PROCÉDÉS ET SYSTÈMES D'ADMINISTRATION D'UNE MÉDICATION PAR INHALATION
  申请人：NEXT SAFETY INC

  公开号：WO2008116165A9

  公开（公告）日：2009-06-11

  [EN] Systems and methods for delivery of a drug to the respiratory system of a patient are provided, where the drug is supplied in purified air at a positive pressure relative to atmospheric pressure. With the systems and methods of the present disclosure, medication available in a variety of forms is introduced in a controlled fashion into the purified air stream in aerosol, nebulized, or vaporized form.
  [FR] L'invention concerne des procédés d'administration d'un médicament au système respiratoire d'un patient, où le médicament est fourni dans de l'air purifié à une pression positive par rapport à la pression atmosphérique. Avec les systèmes et procédés de la présente description, une médication disponible sous une variété de formes est introduite de manière contrôlée dans le courant d'air purifié dans un aérosol, sous forme nébulisée ou vaporisée.