2,2'-difluorodiphenylether | 1138557-63-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-difluorodiphenylether
• 英文别名: Fluorophenyl ether；1-fluoro-2-(2-fluorophenoxy)benzene
• CAS: 1138557-63-7
• 化学式: C₁₂H₈F₂O
• 分子量: 206.192
• InChiKey: CDAOWUNZBZEBDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Process for preparing polyarylene thioethers
  申请人：SEISAN KAIHATSU KAGAKU KENKYUSHO

  公开号：EP0440106A2

  公开（公告）日：1991-08-07

  Polyarylene thioethers are easily prepared by an oxidative polymerization of an aromatic compound of the formula (I) wherein R¹, R², R³ and R⁴ are each independently a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, and Y is a hydrogen atom or a group of the formula (II) wherein R⁵, R⁶, R⁷ and R⁸ are each independently a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group and X is -O-, -S-, a methylene group or an ethylene group with a sulfidizing agent in the presence of an acid and an oxidizing agent, or in the presence of an acid, a catalyst for oxidative polymerization and oxygen, or in the presence of a Friedel-Crafts catalyst.

  通过式 (I) 的芳香族化合物的氧化聚合可轻松制备聚芳硫醚，式 (I) 中 R¹、R²、R³ 和 R⁴ 各自独立地为氢原子、卤素原子、低级烷基或低级烷氧基，Y 为氢原子或式 (II) 的基团，式 (II) 中 R⁵、R⁶、 R⁵、R⁶、R⁷ 和 R⁸ 各自独立地为氢原子、卤素原子、低级烷基或低级烷氧基，X 为-O-、-S-、亚甲基或亚乙基，在有酸和氧化剂存在下，或在有酸、氧化聚合催化剂和氧存在下，或在有 Friedel-Crafts 催化剂存在下，加入硫化剂。
• Preparation process of fluorine subsituted aromatic compound
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1013629A1

  公开（公告）日：2000-06-28

  A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylaminodifluoromethane compound, for example, 2,2'-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.

  本发明公开了一种氟取代芳香族化合物的制备工艺，该工艺包括使具有羟基的芳香族化合物的碱金属盐或碱土金属盐与有机氟化剂反应。作为氟化剂的代表，举例说明了一种双二烷基氨基二氟甲烷化合物，例如 2,2'-二氟-1,3-二甲基咪唑烷。 根据该工艺，工业上有用的氟化芳烃化合物，例如氟苯、氟取代的二苯甲酮、氟取代的二元砜，无需特定设备即可轻松制备，经济实惠。
• DETECTING STRUCTURAL OR SYNTHETIC INFORMATION ABOUT CHEMICAL COMPOUNDS
  申请人：——

  公开号：US20020006614A1

  公开（公告）日：2002-01-17

  The present invention provides an improved system for the rapid and non-destructive identification of chemical compounds attached to solid supports. In general, the invention provides an identification unit comprising a tag attached to the solid support and a binding partner that interacts specifically and detectably with he tag. In preferred embodiments, the identification unit incorporates the advantages of chemically robust tags and a decoding technique capable of amplification for easy detection and analysis. The present invention further provides a kit comprising a collection of tags capable of attachment to a support and binding partners capable of binding selectively and detectably to the tags, to generate an identification unit for the facile determination of the structure of a compound of interest by determining the reaction history and/or structural characteristics of the compounds that are encoded by the identification unit.

  本发明提供了一种改进的系统，用于快速、无损地识别附着在固体支持物上的化 学化合物。一般来说，本发明提供了一种识别单元，包括附着在固体支持物上的标签和能与标签发生特异性和可检测性相互作用的结合剂。在优选的实施方案中，识别单元结合了化学性质稳定的标签和能够放大的解码技术的优点，便于检测和分析。本发明进一步提供了一种试剂盒，该试剂盒包括一系列能够附着在支持物上的标签和能够选择性地、可检测地与标签结合的结合剂，以生成一个识别单元，通过确定由识别单元编码的化合物的反应历史和/或结构特征，方便地确定感兴趣的化合物的结构。
• Device and methods for directed synthesis of chemical libraries
  申请人：——

  公开号：US20030182068A1

  公开（公告）日：2003-09-25

  The invention features a sort computer which interfaces with a sorting device in order to control the sorting of beads on a bead by bead basis. The invention further features novel methods for the directed synthesis of encoded libraries of oligomers, e.g., oligonucleotides, on beads. These methods allow the synthesis of libraries that are sufficiently large to permit complex genomic analyses to be carried out. New methods of using the encoded libraries also are described.

  本发明的特点是分选计算机与分选装置连接，以控制逐珠分选。本发明还具有在珠子上定向合成寡聚体（如寡核苷酸）编码文库的新方法。这些方法可以合成足够大的文库，以便进行复杂的基因组分析。此外，还介绍了使用编码文库的新方法。
• DEVICE AND METHODS FOR DIRECTED SYNTHESIS OF CHEMICAL LIBRARIES
  申请人：Nanomics Biosystems Pty, Ltd.

  公开号：EP1448789A2

  公开（公告）日：2004-08-25