N-(2'-m-phenyl)pyrrolidine | 79092-03-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2'-m-phenyl)pyrrolidine
• 英文别名: 1-(2,6-Diphenylphenyl)pyrrolidine
• CAS: 79092-03-8
• 化学式: C₂₂H₂₁N
• 分子量: 299.415
• InChiKey: FHRLSABUVZIJPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,3-二甲氧基-1,3-二氯丙烷 、 1-[(Z)-1,3-diphenylprop-1-en-2-yl]pyrrolidine 以52%的产率得到
  参考文献：
  名称：

  CAMPS P.; JAIME C.; MOLAS J., TETRAHEDRON LETT., 1981, 22, NO 26, 2487-2490

  摘要：

  DOI：

文献信息

• A one-step synthesis of 2,6-disubstituted anilines from aliphatic compounds
  作者：P. Camps、C. Jaime、J. Molas

  DOI：10.1016/s0040-4039(01)92940-5

  日期：1981.1

  A one-step synthesis of 2,6-disubstituted anilines by reaction of enamines derived from acyclic ketones of the type RCH2COCH2R' and 1,3-dichloro-1,3-dimethoxypropane is described.

  描述了通过衍生自RCH 2 COCH 2 R'类型的无环酮与1,3-二氯-1,3-二甲氧基丙烷的烯胺反应来一步合成2,6-二取代的苯胺。
• COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：US20180194775A1

  公开（公告）日：2018-07-12

  Provision of orally-available and low-toxic somatostatin receptor subtype 2 agonist. Since the compound represented by the general formula (I): wherein all symbols represent the same meanings as those described in the description, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof is non-peptidic low-molecular compound which has strong somatostatin receptor subtype 2 agonist activity, the compound is orally-available. Additionally, since the compound is low-toxic, the compound is useful for the prevention and/or treatment of the somatostatin related diseases such as acromegaly or gastrointestinal obstruction.