(2S)-2-{4-chloro-5-[(4-cyano-1,3-dimethyl-1H-pyrazol-5-yl)oxy]-2-ethylphenoxy}propionic acid | 1043917-17-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-2-{4-chloro-5-[(4-cyano-1,3-dimethyl-1H-pyrazol-5-yl)oxy]-2-ethylphenoxy}propionic acid
• 英文别名: (2S)-2-[4-chloro-5-(4-cyano-2,5-dimethylpyrazol-3-yl)oxy-2-ethylphenoxy]propanoic acid
• CAS: 1043917-17-4
• 化学式: C₁₇H₁₈ClN₃O₄
• 分子量: 363.801
• InChiKey: KXHOTCCEYCBKPQ-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  97.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• PYRAZOLE COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2128138A1

  公开（公告）日：2009-12-02

  The present invention aims to provide an agent for the prophylaxis or treatment of diabetes, which has a superior hypoglycemic action, and is associated with a fewer side effects such as body weight gain and the like. The present invention relates to an agent for the prophylaxis or treatment of diabetes comprising a compound represented by the formula: wherein each symbol is as defined in the description, or a salt thereof, or a prodrug thereof.

  本发明旨在提供一种用于预防或治疗糖尿病的药物，具有优越的降血糖作用，并且与较少的副作用，如体重增加等相关。本发明涉及一种用于预防或治疗糖尿病的药物，包括由以下式表示的化合物：其中每个符号如描述中所定义，或其盐，或其前药。
• Organoselenium compounds for cancer chemoprevention
  申请人：LKT Laboratories, Inc.

  公开号：US20020165215A1

  公开（公告）日：2002-11-07

  A compound containing an alkylene selenocyanate or an alkylene isoselenocyanate moiety effective to prevent the occurrence or progression of cancer or a precancerous condition. The compound can be provided and administered in the form of a pharmaceutical composition, a cosmetic, a food additive, supplement, or the like. Methods for synthesis and use of the chemopreventive compound of the invention are also provided.

  一种含有烷基硒氰酸酯或烷基异硒氰酸酯基团的化合物，可有效预防或阻止癌症或癌前病变的发生或进展。该化合物可以以药物组成物、化妆品、食品添加剂、补充剂等形式提供和施用。本发明还提供了合成和使用化学预防化合物的方法。
• Organoselenium compound for cancer chemoprevention
  申请人：Lam K.T. Luke

  公开号：US20080108692A1

  公开（公告）日：2008-05-08

  A compound containing an alkylene selenocyanate or an alkylene isoselenocyanate moiety effective to prevent the occurrence or progression of cancer or a precancerous condition. The compound can be provided and administered in the form of a pharmaceutical composition, a cosmetic, a food additive, supplement, or the like. Methods for synthesis and use of the chemopreventive compound of the invention are also provided.
• US6703524B2
  申请人：——

  公开号：US6703524B2

  公开（公告）日：2004-03-09
• US7087639B2
  申请人：——

  公开号：US7087639B2

  公开（公告）日：2006-08-08