methyl (S)-2-methyl-2-[3-(formylmethyl)-3-(2-nitrobenzenesulfonyl)amino-2-oxoazetidin-1-yl]propanoate | 1355585-76-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl (S)-2-methyl-2-[3-(formylmethyl)-3-(2-nitrobenzenesulfonyl)amino-2-oxoazetidin-1-yl]propanoate
• 英文别名: methyl 2-methyl-2-[(3S)-3-[(2-nitrophenyl)sulfonylamino]-2-oxo-3-(2-oxoethyl)azetidin-1-yl]propanoate
• CAS: 1355585-76-0
• 化学式: C₁₆H₁₉N₃O₈S
• 分子量: 413.408
• InChiKey: NNFXJENDPSJSRP-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  164
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• New cyclotetrapeptides with pro-angiogenic properties
  申请人：GENETADI Biotech, S.L.

  公开号：EP2407478A1

  公开（公告）日：2012-01-18

  New cyclotetrapeptides of formula (I) or their pharmaceutically acceptable salts, cyclo [Arg-Asp-(beta-Lactam)] (I) wherein (beta-Lactam) is a biradical of the formula (II) wherein the terminal NH group of the (beta-Lactam) is attached to the α-carbonyl group of the aspartic residue (Asp), and the terminal carbonyl group of the (beta-Lactam) is attached to the α-amino group the arginine residue (Arg); processes for their preparation, and pharmaceutical compositions containing them, as well as the said cyclotetrapeptides for use in human and animal therapy.

  新的环四肽化合物的化学式(I)或其药用盐，环[精-天冬氨酸-(β-内酰胺)](I)，其中(β-内酰胺)是化学式(II)的双自由基，其中(β-内酰胺)的末端NH基团连接到天冬氨酸残基(Asp)的α-羰基团，(β-内酰胺)的末端羰基团连接到精氨酸残基(Arg)的α-氨基团；它们的制备方法，含有它们的药物组合物，以及所述环四肽用于人类和动物治疗的用途。
• CYCLOTETRAPEPTIDES WITH PRO-ANGIOGENIC PROPERTIES
  申请人：Aizpurua Iparraguirre Jesús María

  公开号：US20130172273A1

  公开（公告）日：2013-07-04

  Cyclotetrapeptides of formula (I) or their pharmaceutically acceptable salts, cyclo[Arg-Asp-(beta-Lactam)] (I) wherein (beta-Lactam) is a biradical of the formula (II) wherein the terminal NH group of the (beta-Lactam) is attached to the α-carbonyl group of the aspartic residue (Asp), and the terminal carbonyl group of the (beta-Lactam) is attached to the α-amino group the arginine residue (Arg); processes for their preparation, and pharmaceutical compositions containing them, as well as their use in human and animal therapy.

  公式（I）的环四肽或其药学上可接受的盐，环[Arg-Asp-(β-内酰胺)]（I），其中（β-内酰胺）是公式（II）的双自由基，其中（β-内酰胺）的末端NH基团连接到天冬氨酸残基（Asp）的α-羰基基团上，而（β-内酰胺）的末端羰基基团连接到精氨酸残基（Arg）的α-氨基基团上；它们的制备方法，以及含有它们的药物组合物，以及它们在人类和动物治疗中的用途。
• [EN] CYCLOTETRAPEPTIDES WITH PRO-ANGIOGENIC PROPERTIES<br/>[FR] CYCLOTÉTRAPEPTIDES PRÉSENTANT DES PROPRIÉTÉS PRO-ANGIOGÉNIQUES
  申请人：GENETADI BIOTECH S L

  公开号：WO2012007562A1

  公开（公告）日：2012-01-19

  Cyclotetrapeptides of formula (I) or their pharmaceutically acceptable salts, cyclo[Arg-Asp-(beta-Lactam)] (I) wherein (beta-Lactam) is a biradical of the formula (II) wherein the terminal NH group of the (beta-Lactam) is attached to the α- carbonyl group of the aspartic residue (Asp), and the terminal carbonyl group of the (beta-Lactam) is attached to the α-amino group the arginine residue (Arg); processes for their preparation, and pharmaceutical compositions containing them, as well as their use in human and animal therapy.